The emerging role of autophagy in the pathophysiology of diabetes mellitus
CD Gonzalez, MS Lee, P Marchetti, M Pietropaolo… - Autophagy, 2011 - Taylor & Francis
An emerging body of evidence supports a role for autophagy in the pathophysiology of type
1 and type 2 diabetes mellitus. Persistent high concentrations of glucose lead to imbalances …
1 and type 2 diabetes mellitus. Persistent high concentrations of glucose lead to imbalances …
The VMP1-Beclin 1 interaction regulates autophagy induction
MI Molejon, A Ropolo, AL Re, V Boggio, MI Vaccaro - Scientific reports, 2013 - nature.com
Abstract The Vacuole Membrane Protein 1-VMP1-is a pancreatitis-associated
transmembrane protein whose expression triggers autophagy in several human diseases. In …
transmembrane protein whose expression triggers autophagy in several human diseases. In …
[HTML][HTML] VMP1 affects endoplasmic reticulum stress sensitivity via differential modulation of the three unfolded protein response arms
T Li, H Zhao, G Guo, S Xia, L Wang - Cell Reports, 2023 - cell.com
Consisting of three signaling pathways, the unfolded protein response (UPR) can be either
protective or detrimental to cells that undergo ER stress. Elaborate regulation of the UPR is …
protective or detrimental to cells that undergo ER stress. Elaborate regulation of the UPR is …
Involvement of TGF-β and autophagy pathways in pathogenesis of diabetes: a comprehensive review on biological and pharmacological insights
F Heydarpour, S Sajadimajd, E Mirzarazi… - Frontiers in …, 2020 - frontiersin.org
Despite recent advancements in clinical drugs, diabetes treatment still needs further
progress. As such, ongoing research has attempted to determine the precise molecular …
progress. As such, ongoing research has attempted to determine the precise molecular …
A novel source for miR-21 expression through the alternative polyadenylation of VMP1 gene transcripts
J Ribas, X Ni, M Castanares, MM Liu… - Nucleic acids …, 2012 - academic.oup.com
Abstract miR-21 is the most commonly over-expressed microRNA (miRNA) in cancer and a
proven oncogene. Hsa-miR-21 is located on chromosome 17q23. 2, immediately …
proven oncogene. Hsa-miR-21 is located on chromosome 17q23. 2, immediately …
Novel AKT1-GLI3-VMP1 pathway mediates KRAS oncogene-induced autophagy in cancer cells
AEL Ré, MG Fernández-Barrena, LL Almada… - Journal of Biological …, 2012 - ASBMB
Background: Autophagy plays a role in cancer development. Results: Oncogenic KRAS
induces Vacuole Membrane Protein 1 (VMP1) through a novel AKT1-GLI3-p300 pathway …
induces Vacuole Membrane Protein 1 (VMP1) through a novel AKT1-GLI3-p300 pathway …
[HTML][HTML] Autophagy in pancreatic cancer pathogenesis and treatment
Pancreatic cancer is the fourth most common cancer to cause death due to advanced stage
at diagnosis and poor response to current treatment. Autophagy is the lysosome-mediated …
at diagnosis and poor response to current treatment. Autophagy is the lysosome-mediated …
Ubiquitylation of nuclear receptors: new linkages and therapeutic implications
KT Helzer, C Hooper, S Miyamoto… - Journal of molecular …, 2015 - jme.bioscientifica.com
Autophagy is an important cellular process involving the degradation of intracellular
components. Its regulation is complex and while there are many methods available, there is …
components. Its regulation is complex and while there are many methods available, there is …
A novel E2F1-EP300-VMP1 pathway mediates gemcitabine-induced autophagy in pancreatic cancer cells carrying oncogenic KRAS
A Ropolo, C Catrinacio, FJ Renna, V Boggio… - Frontiers in …, 2020 - frontiersin.org
Autophagy is an evolutionarily preserved degradation process of cytoplasmic cellular
constituents, which participates in cell response to disease. We previously characterized …
constituents, which participates in cell response to disease. We previously characterized …