Is protein context responsible for peptide-mediated interactions?
Many cell signaling pathways are orchestrated by the weak, transient, and reversible protein–
protein interactions that are mediated by the binding of a short peptide segment in one …
protein interactions that are mediated by the binding of a short peptide segment in one …
Structure-based discovery of substituted 4, 5′-bithiazoles as novel DNA gyrase inhibitors
M Brvar, A Perdih, M Renko, G Anderluh… - Journal of medicinal …, 2012 - ACS Publications
Bacterial DNA gyrase is a well-established and validated target for the development of novel
antibacterials. Starting from the available structural information about the binding of the …
antibacterials. Starting from the available structural information about the binding of the …
Context contribution to the intermolecular recognition of human ACE2-derived peptides by SARS-CoV-2 spike protein: implications for improving the peptide affinity …
P Zhou, H Wang, Z Chen, Q Liu - Molecular Omics, 2021 - pubs.rsc.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an etiological agent of
the current rapidly growing outbreak of coronavirus disease (COVID-19), which is straining …
the current rapidly growing outbreak of coronavirus disease (COVID-19), which is straining …
[HTML][HTML] Evaluation of the antibacterial activity of patchouli oil
X Yang, X Zhang, SP Yang, WQ Liu - Iranian journal of …, 2013 - ncbi.nlm.nih.gov
In the present study, the antimicrobial tests of patchouli oil were studied by using molecular
docking technology and antimicrobial test in vitro. Five biological macromolecule enzymes …
docking technology and antimicrobial test in vitro. Five biological macromolecule enzymes …
Why the first self-binding peptide of human c-Src kinase does not contain class II motif but can bind to its cognate Src homology 3 domain in class II mode?
P Zhou, F Yan, Q Miao, Z Chen… - Journal of Biomolecular …, 2021 - Taylor & Francis
Abstract Src homology 3 (SH3) domains are small protein modules involved in the
regulation of important cellular pathways such as proliferation and migration, which …
regulation of important cellular pathways such as proliferation and migration, which …
Structure-based derivation and intramolecular cyclization of peptide inhibitors from PD-1/PD-L1 complex interface as immune checkpoint blockade for breast cancer …
K Zhou, J Lu, X Yin, H Xu, L Li, B Ma - Biophysical chemistry, 2019 - Elsevier
The interaction event between programmed death receptor-1 (PD-1) and its ligand (PD-L1)
functions as an essential immune checkpoint against cytotoxic T effector cell activation …
functions as an essential immune checkpoint against cytotoxic T effector cell activation …
Behavioral toxicity of TDCPP in marine zooplankton: Evidence from feeding and swimming responses, molecular dynamics and metabolomics of rotifers
X Zhang, X Tong, X Tang, Y Yang, L Zhang… - Science of The Total …, 2024 - Elsevier
As new organic flame retardants, chlorinated organophosphate esters (Cl-OPEs) have high
water solubility and structural similarity to organophosphate pesticides, posing risks to …
water solubility and structural similarity to organophosphate pesticides, posing risks to …
Exploring the cause of the inhibitor 4AX attaching to binding site disrupting protein tyrosine phosphatase 4A1 trimerization by molecular dynamic simulation
L Wei-Ya, D Yu-Qing, M Yang-Chun… - Journal of …, 2019 - Taylor & Francis
Ectopic overexpression of protein tyrosine phosphatase of liver regeneration-1 (PTP4A1,
also called PRL-1) markedly enhanced hepatocellular carcinoma (HCC) cells migration and …
also called PRL-1) markedly enhanced hepatocellular carcinoma (HCC) cells migration and …
Effect-Directed Synthesis of PhoP/PhoQ Inhibitors to Regulate Salmonella Virulence
I Cabezudo, CA Lobertti, EG Véscovi… - Journal of Agricultural …, 2022 - ACS Publications
Salmonella spp. are among the leading bacterial causes of foodborne infections. The
PhoP/PhoQ two-component regulatory system serves as a master virulence regulator in …
PhoP/PhoQ two-component regulatory system serves as a master virulence regulator in …
Design, synthesis, biological evaluation, common feature pharmacophore model and molecular dynamics simulation studies of ethyl 4-(phenoxymethyl)-2 …
J Wu, W Li, Z Zheng, X Lu, H Zhang, Y Ma… - Journal of …, 2021 - Taylor & Francis
SHP2 is a non-receptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene
involved in cell death pathway (PD-1/PD-L1) and cell growth and differentiation pathway …
involved in cell death pathway (PD-1/PD-L1) and cell growth and differentiation pathway …