The variety of taste sensations, including sweet, umami, bitter, sour, and salty, arises from
diverse taste cells, each of which expresses specific taste sensor molecules and associated …

Taste buds are aggregates of 50–100 polarized neuroepithelial cells that detect nutrients
and other compounds. Combined analyses of gene expression and cellular function reveal …

Adenosine triphosphate (ATP) has been well established as an important extracellular
ligand of autocrine signaling, intercellular communication, and neurotransmission with …

Three family members compose the pannexin family of channel-forming glycoproteins
(Panx1, Panx2 and Panx3). Their primary function is defined by their capacity to form single …

Abstract The nucleotide adenosine 5′-triphosphate (ATP) has classically been considered
the cell's primary energy currency. Importantly, a novel role for ATP as an extracellular …

Binding of sweet, umami, and bitter tastants to G protein-coupled receptors (GPCRs) in
apical membranes of type II taste bud cells (TBCs) triggers action potentials that activate a …

Purpose Microglia represent the primary resident immune cells in the CNS, and have been
implicated in the pathology of neurodegenerative diseases. Under basal or “resting” …

Taste buds are the transducing endorgans of gustation. Each taste bud comprises 50–100
elongated cells, which extend from the basal lamina to the surface of the tongue, where their …

Food preferences and dietary habits are heavily influenced by taste perception. There is
growing interest in characterizing taste preferences based on genetic variation. Genetic …

Taste buds are peripheral chemosensory organs situated in the oral cavity. Each taste bud
consists of a community of 50–100cells that interact synaptically during gustatory …