Tutorial: best practices and considerations for mass-spectrometry-based protein biomarker discovery and validation
Mass-spectrometry-based proteomic analysis is a powerful approach for discovering new
disease biomarkers. However, certain critical steps of study design such as cohort selection …
disease biomarkers. However, certain critical steps of study design such as cohort selection …
Identification of bioactive metabolites using activity metabolomics
The metabolome, the collection of small-molecule chemical entities involved in metabolism,
has traditionally been studied with the aim of identifying biomarkers in the diagnosis and …
has traditionally been studied with the aim of identifying biomarkers in the diagnosis and …
Opportunities and obstacles for deep learning in biology and medicine
T Ching, DS Himmelstein… - Journal of the …, 2018 - royalsocietypublishing.org
Deep learning describes a class of machine learning algorithms that are capable of
combining raw inputs into layers of intermediate features. These algorithms have recently …
combining raw inputs into layers of intermediate features. These algorithms have recently …
Multi‐Omics Factor Analysis—a framework for unsupervised integration of multi‐omics data sets
Multi‐omics studies promise the improved characterization of biological processes across
molecular layers. However, methods for the unsupervised integration of the resulting …
molecular layers. However, methods for the unsupervised integration of the resulting …
Integrated omics: tools, advances and future approaches
With the rapid adoption of high-throughput omic approaches to analyze biological samples
such as genomics, transcriptomics, proteomics, and metabolomics, each analysis can …
such as genomics, transcriptomics, proteomics, and metabolomics, each analysis can …
Integrating artificial intelligence and nanotechnology for precision cancer medicine
Artificial intelligence (AI) and nanotechnology are two fields that are instrumental in realizing
the goal of precision medicine—tailoring the best treatment for each cancer patient. Recent …
the goal of precision medicine—tailoring the best treatment for each cancer patient. Recent …
Machine learning applications for mass spectrometry-based metabolomics
The metabolome of an organism depends on environmental factors and intracellular
regulation and provides information about the physiological conditions. Metabolomics helps …
regulation and provides information about the physiological conditions. Metabolomics helps …
Machine learning and integrative analysis of biomedical big data
Recent developments in high-throughput technologies have accelerated the accumulation
of massive amounts of omics data from multiple sources: genome, epigenome …
of massive amounts of omics data from multiple sources: genome, epigenome …
Perspective of artificial intelligence in healthcare data management: A journey towards precision medicine
Mounting evidence has highlighted the implementation of big data handling and
management in the healthcare industry to improve the clinical services. Various private and …
management in the healthcare industry to improve the clinical services. Various private and …
Machine and deep learning meet genome-scale metabolic modeling
Omic data analysis is steadily growing as a driver of basic and applied molecular biology
research. Core to the interpretation of complex and heterogeneous biological phenotypes …
research. Core to the interpretation of complex and heterogeneous biological phenotypes …