Orofacial pain refers to pain occurring in the head and face, which is highly prevalent and
represents a challenge to clinicians, but its underlying mechanisms are not fully understood …

Introduction G protein-coupled receptors (GPCRs) are the target of one-third of all approved
drugs; however, these drugs only target about one-eighth of the human repertoire of GPCRs …

A robust cell-free platform technology, ribosome display in combination with cloning,
expression, and purification was utilized to develop single chain Fragment variable (scFv) …

Non-opioid single-chain variable fragment (scFv) small antibodies were generated as pain-
reducing block of P2X4R receptor (P2X4R). A panel of scFvs targeting an extracellular …

Cholecystokinin (CCK) is a peptide that has been implicated in pain modulation. Acid
sensitive ion channels (ASICs) also play an important role in pain associated with tissue …

The cholecystokinin receptor system, specifically cholecystokinin 2 receptor (CCK2R) is a
historic target for pain management that has shown limited success. However, new …

Monoclonal antibody biologics have significantly transformed the therapeutic landscape
within the biopharmaceutical industry, partly due to the utilisation of discovery technologies …

目的建立一种以单链抗体为基础的酶联免疫吸附法(enzyme linked immunosorbent assay,
ELISA) 快速检测畜禽产品中西马特罗(cimaterol, CIM) 药物残留. 方法以重氮化法合成的西马特 …

The role of adipose issue for fat storage and energy production is well known, but this
classic function doesn't reflect its significant effects as an endocrine tissue as well as …