Robust brain development requires the tight coordination between tissue growth, neuronal
differentiation and stem cell maintenance. To achieve this, neural stem cells need to balance …

Notch signaling plays crucial roles in fate determination and the differentiation of neural
stem cells in embryonic and adult brains. It is now clear that the notch pathway is under …

Developmental pathways such as Notch play a pivotal role in tissue-specific stem cell self-
renewal as well as in tumor development. However, the role of Notch signaling in breast …

Background Live imaging provides an essential methodology for understanding complex
and dynamic cell behaviors and their underlying molecular mechanisms. Genetically …

Organ renewal is governed by the dynamics of cell division, differentiation and loss. To study
these dynamics in real time, we present a platform for extended live imaging of the adult …

During embryogenesis cells make fate decisions within complex tissue environments. The
levels and dynamics of transcription factor expression regulate these decisions. Here, we …

The FGF/ERK signaling pathway is highly conserved throughout evolution and plays
fundamental roles during embryonic development and in adult organisms. While a plethora …

The role of MYC proteins in somatic stem and progenitor cells during development is poorly
understood. We have taken advantage of a chick in vivo model to examine their role in …

Abstract Development of the cerebral cortex requires regulation of proliferation and
differentiation of neural stem cells and a diverse range of progenitors. Recent work suggests …

Unequal centrosome maturation correlates with asymmetric division in multiple cell types.
Nevertheless, centrosomal fate determinants have yet to be identified. Here, we show that …