Ticks are ectoparasitic arthropods that necessarily feed on the blood of their vertebrate
hosts. The success of blood acquisition depends on the pharmacological properties of tick …

Ixodes scapularis and Ixodes pacificus are the predominant vectors of multiple human
pathogens, including Borrelia burgdorferi, one of the causative agents of Lyme disease in …

The main importance of ticks resides in their ability to harbor pathogens that can be
transmitted to terrestrial vertebrates including humans. Recently, studies have focused on …

Disease-transmitting vectors are living organisms that pass infectious agents from one
animal/human to another. The epidemiologically important vectors are usually …

Papain-like cysteine peptidases form a big and highly diverse superfamily of proteins
involved in many important biological functions, such as protein turnover, deubiquitination …

In mammals, cyclic dinucleotides (CDNs) bind and activate STING to initiate an antiviral type
I interferon response. CDNs and STING originated in bacteria and are present in most …

Tick-transmitted bacterial pathogens thrive in enzootic infection cycles, colonizing disparate
vertebrate and arthropod tissues, often establishing persistent infections. Therefore, the …

Background Microbial communities can affect disease risk by interfering with the
transmission or maintenance of pathogens in blood-feeding arthropods. Here, we …

Background The impact of host skin microbiome on horizontal transmission of tick-borne
pathogens, and of pathogen associated transstadial and transovarial changes in tick …

Ticks are obligate hematophagous arthropods that transmit a wide range of pathogens to
humans as well as wild and domestic animals. They also harbor a non-pathogenic …