An epidemic of obesity has affected large portions of the world, increasing the risk of
developing many different age-associated diseases, including cancer, cardiovascular …

Intermittent and periodic fasting (IF and PF, respectively) are emerging as safe strategies to
affect longevity and healthspan by acting on cellular aging and disease risk factors, while …

Low-protein diets promote metabolic health in rodents and humans, and the benefits of low-
protein diets are recapitulated by specifically reducing dietary levels of the three branched …

Dietary restriction (DR) decreases body weight, improves health, and extends lifespan. DR
can be achieved by controlling how much and/or when food is provided, as well as by …

The importance of dietary composition and feeding patterns in aging remains largely
unexplored, but was implicated recently in two prominent nonhuman primate studies. Here …

Key points We recently found that feeding healthy mice a diet with reduced levels of
branched-chain amino acids (BCAAs), which are associated with insulin resistance in both …

Summary Protein-restricted (PR), high-carbohydrate diets improve metabolic health in
rodents, yet the precise dietary components that are responsible for these effects have not …

Calorie restriction (CR) is the most robust non-genetic intervention to delay aging. However,
there are a number of emerging experimental variables that alter CR responses. We …

Alzheimer's disease (AD) is one of the fastest growing cognitive decline-related neurological
diseases. To date, effective curative strategies have remained elusive. A growing body of …

Low-protein diets promote metabolic health in humans and rodents. Despite evidence that
sex and genetic background are key factors in the response to diet, most protein intake …