The use of animal models to study diseases is fundamental to the advancement of the
understanding of basic biologic mechanisms and disease-specific dysfunctions and to the …

In 1972 Guido Biozzi selectively bred mice to study the immunopathological mechanisms
underlying polygenic diseases. One line, the Biozzi antibody high (AB/H) mouse (now …

High-throughput genomics allows genome-wide quantification of gene expression levels in
tissues and cell types and, when combined with sequence variation data, permits the …

B cells are major players in T1D in humans, and clearly essential for disease development
in the NOD mouse model of T1D. In this review, we discuss the silencing of autoreactive B …

We can now predict the development of type 1 diabetes in man because it is a chronic
autoimmune disorder with defined stages of disease. We can also readily prevent the …

The nonobese diabetic mouse spontaneously develops an autoimmune, T-cell-mediated
type 1 diabetes (T1D). Common and rare alleles both within a diabetogenic major …

Comparative mapping between the human and rodent genomes is one approach for
positional cloning of complex disease loci. The human type 1 diabetes susceptibility locus …

Penetrance of the complex of genes predisposing the nonobese diabetic (NOD) mouse to
autoimmune diabetes is affected by the maternal environment. NOD. CBALs-Tyr+/Lt is an …

Congenic mouse strains provide a unique resource for genetic dissection and biological
characterization of chromosomal regions associated with diabetes progression in the …

Abstract Context: Congenic NOD. ABH D18Mit8-D18Mit214 mice, which contain greater
than 12.8 Mb of DNA encompassing Idd21. 1 from diabetes-resistant Biozzi/ABH mice, have …