Pathogenesis of cancers derived from thyroid follicular cells

JA Fagin, GP Krishnamoorthy, I Landa - Nature reviews Cancer, 2023 - nature.com
The genomic simplicity of differentiated cancers derived from thyroid follicular cells offers
unique insights into how oncogenic drivers impact tumour phenotype. Essentially, the main …

Thyroid autoimmune disorders and cancer

SM Ferrari, P Fallahi, G Elia, F Ragusa, I Ruffilli… - Seminars in cancer …, 2020 - Elsevier
In the last decades, many studies conducted in vitro, and in vivo, have shown that thyroid
autoimmunity and thyroid cancer (TC)(mainly papillary TC) can be concomitant, even if the …

Small effects: The indispensable foundation for a cumulative psychological science

FM Götz, SD Gosling… - … on psychological science, 2022 - journals.sagepub.com
We draw on genetics research to argue that complex psychological phenomena are most
likely determined by a multitude of causes and that any individual cause is likely to have …

LncRNA SLC26A4-AS1 suppresses the MRN complex-mediated DNA repair signaling and thyroid cancer metastasis by destabilizing DDX5

J Yuan, Y Song, W Pan, Y Li, Y Xu, M Xie, Y Shen… - Oncogene, 2020 - nature.com
Lymph node metastasis is the major adverse feature for recurrence and death of thyroid
cancer patients. To identify lncRNAs involved in thyroid cancer metastasis, we systemically …

Genotyping of circulating tumor DNA in cholangiocarcinoma reveals diagnostic and prognostic information

TJ Ettrich, D Schwerdel, A Dolnik, F Beuter, TJ Blätte… - Scientific reports, 2019 - nature.com
Diagnosis of Cholangiocarcinoma (CCA) is difficult, thus a noninvasive approach towards (i)
assessing and (ii) monitoring the tumor-specific mutational profile is desirable to improve …

Yap governs a lineage-specific neuregulin1 pathway-driven adaptive resistance to RAF kinase inhibitors

MER Garcia-Rendueles, G Krishnamoorthy… - Molecular Cancer, 2022 - Springer
Abstract Background Inactivation of the Hippo pathway promotes Yap nuclear translocation,
enabling execution of a transcriptional program that induces tissue growth. Genetic lesions …

Current knowledge of germline genetic risk factors for the development of non-medullary thyroid cancer

K Hińcza, A Kowalik, A Kowalska - Genes, 2019 - mdpi.com
The thyroid is the most common site of endocrine cancer. One type of thyroid cancer, non-
medullary thyroid cancer (NMTC), develops from follicular cells and represents …

Septin11 promotes hepatocellular carcinoma cell motility by activating RhoA to regulate cytoskeleton and cell adhesion

L Fu, X Wang, Y Yang, MH Chen, A Kuerban… - Cell Death & …, 2023 - nature.com
Septins as GTPases in the cytoskeleton, are linked to a broad spectrum of cellular functions,
including cell migration and the progression of hepatocellular carcinoma (HCC). However …

Heavy metals in the environment and thyroid cancer

F Gianì, R Masto, MA Trovato, P Malandrino, M Russo… - Cancers, 2021 - mdpi.com
Simple Summary Epidemiological observations indicate that the incidence of thyroid cancer
is increased in volcanic areas. Indeed, in the volcanic area of Sicily, where residents are …

Genome-wide association studies of autoimmune thyroid diseases, thyroid function, and thyroid cancer

Y Hwangbo, YJ Park - Endocrinology and Metabolism, 2018 - synapse.koreamed.org
Thyroid diseases, including autoimmune thyroid diseases and thyroid cancer, are known to
have high heritability. Family and twin studies have indicated that genetics plays a major …