Pseudomonas aeruginosa: pathogenesis, virulence factors, antibiotic resistance, interaction with host, technology advances and emerging therapeutics

S Qin, W Xiao, C Zhou, Q Pu, X Deng, L Lan… - Signal transduction and …, 2022 - nature.com
Pseudomonas aeruginosa (P. aeruginosa) is a Gram-negative opportunistic pathogen that
infects patients with cystic fibrosis, burn wounds, immunodeficiency, chronic obstructive …

Antimicrobial stewardship: fighting antimicrobial resistance and protecting global public health

MAA Majumder, S Rahman, D Cohall… - Infection and drug …, 2020 - Taylor & Francis
Antimicrobial resistance (AMR) is a serious threat to global public health. It increases
morbidity and mortality, and is associated with high economic costs due to its health care …

Hypoalbuminemia as surrogate and culprit of infections

CJ Wiedermann - International journal of molecular sciences, 2021 - mdpi.com
Hypoalbuminemia is associated with the acquisition and severity of infectious diseases, and
intact innate and adaptive immune responses depend on albumin. Albumin oxidation and …

Efflux pump inhibitors for bacterial pathogens: From bench to bedside

A Sharma, VK Gupta, R Pathania - Indian Journal of Medical …, 2019 - journals.lww.com
With the advent of antibiotics, bacterial infections were supposed to be a thing of past.
However, this instead led to the selection and evolution of bacteria with mechanisms to …

Vulnerability of the industrialized microbiota

JL Sonnenburg, ED Sonnenburg - Science, 2019 - science.org
BACKGROUND The collection of trillions of microbes inhabiting the human gut, called the
microbiome or microbiota, has captivated the biomedical research community for the past …

Strategies to prevent healthcare-associated infections: a narrative overview

M Haque, J McKimm, M Sartelli, S Dhingra… - … and healthcare policy, 2020 - Taylor & Francis
Healthcare-associated infections (HCAIs) are a major source of morbidity and mortality and
are the second most prevalent cause of death. Furthermore, it has been reported that for …

A protein-free vaccine stimulates innate immunity and protects against nosocomial pathogens

J Yan, TB Nielsen, P Lu, Y Talyansky… - Science translational …, 2023 - science.org
Traditional vaccines are difficult to deploy against the diverse antimicrobial-resistant,
nosocomial pathogens that cause health care–associated infections. We developed a …

Burden of Clostridioides difficile infection (CDI) - a systematic review of the epidemiology of primary and recurrent CDI

E Finn, FL Andersson, M Madin-Warburton - BMC infectious diseases, 2021 - Springer
Background Clostridioides difficile is a Gram-positive anaerobic bacterium, which causes
Clostridioides difficile infection (CDI). It has been recognised as a leading cause of …

Why do ventilation strategies matter in controlling infectious airborne particles? A comprehensive numerical analysis in isolation ward

H Tan, KY Wong, MHD Othman, HY Kek… - Building and …, 2023 - Elsevier
A proper ventilation strategy in an isolation ward could promote better indoor air quality for
the occupants. This could also reduce the risk of immunocompromised patients contracting …

A major mechanism for immunomodulation: Dietary fibres and acid metabolites

L Xie, MJ Alam, FZ Marques, CR Mackay - Seminars in Immunology, 2023 - Elsevier
Diet and the gut microbiota have a profound influence on physiology and health, however,
mechanisms are still emerging. Here we outline several pathways that gut microbiota …