Inflammation as a regulator of hematopoietic stem cell function in disease, aging, and clonal selection

F Caiado, EM Pietras, MG Manz - Journal of Experimental Medicine, 2021 - rupress.org
Inflammation is an evolutionarily selected defense response to infection or tissue damage
that involves activation and consumption of immune cells in order to reestablish and …

Hypertension and aging

TW Buford - Ageing research reviews, 2016 - Elsevier
Hypertension is a highly prevalent condition with numerous health risks, and the incidence
of hypertension is greatest among older adults. Traditional discussions of hypertension have …

[HTML][HTML] Inflammation–nature's way to efficiently respond to all types of challenges: implications for understanding and managing “the epidemic” of chronic diseases

JM Bennett, G Reeves, GE Billman… - Frontiers in …, 2018 - frontiersin.org
Siloed or singular system approach to disease management is common practice,
developing out of traditional medical school education. Textbooks of medicine describe a …

[HTML][HTML] (Dis) Trust your gut: the gut microbiome in age-related inflammation, health, and disease

TW Buford - Microbiome, 2017 - Springer
Chronic inflammation represents one of the most consistent biologic features of aging.
However, the precise etiology of persistent low-grade increases in inflammation remains …

Hs-CRP and all-cause, cardiovascular, and cancer mortality risk: a meta-analysis

Y Li, X Zhong, G Cheng, C Zhao, L Zhang, Y Hong… - Atherosclerosis, 2017 - Elsevier
Background and aims Inconsistent findings have been reported on the association between
high-sensitivity C-reactive protein (hs-CRP) and mortality risk. The objective of this meta …

[HTML][HTML] Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

T Tchkonia, Y Zhu, J Van Deursen… - The Journal of …, 2013 - Am Soc Clin Investig
Aging is the largest risk factor for most chronic diseases, which account for the majority of
morbidity and health care expenditures in developed nations. New findings suggest that …

[HTML][HTML] Resveratrol and its effects on the vascular system

JM Breuss, AG Atanasov, P Uhrin - International journal of molecular …, 2019 - mdpi.com
Resveratrol, the phenolic substance isolated initially from Veratrum grandiflorum and richly
present in grapes, wine, peanuts, soy, and berries, has been attracting attention of scientists …

[HTML][HTML] Systemic effects of inflammation on health during chronic HIV infection

SG Deeks, R Tracy, DC Douek - Immunity, 2013 - cell.com
Combination antiretroviral therapy for HIV infection improves immune function and
eliminates the risk of AIDS-related complications but does not restore full health. HIV …

[HTML][HTML] Aging of mice is associated with p16 (Ink4a)-and β-galactosidase-positive macrophage accumulation that can be induced in young mice by senescent cells

BM Hall, V Balan, AS Gleiberman, E Strom… - Aging (Albany …, 2016 - ncbi.nlm.nih.gov
Senescent cells (SCs) have been considered a source of age-related chronic sterile
systemic inflammation and a target for anti-aging therapies. To understand mechanisms …

[HTML][HTML] Impact of aging on immunity in the context of COVID-19, HIV, and tuberculosis

A Grifoni, T Alonzi, G Alter, DMC Noonan… - Frontiers in …, 2023 - frontiersin.org
Knowledge of aging biology needs to be expanded due to the continuously growing number
of elderly people worldwide. Aging induces changes that affect all systems of the body. The …