Food allergy is a major health issue, affecting the lives of 8% of US children and their
families. There is an urgent need to identify the environmental and endogenous signals that …

The long-term effectiveness of antibody responses relies on the development of humoral
immune memory. Humoral immunity is maintained by long-lived plasma cells that secrete …

Abs are immune system proteins that recognize noxious molecules for elimination. Their
sequence diversity and binding versatility have made Abs the primary class of …

IgE antibodies may elicit potent allergic reactions, and their production is tightly controlled.
The tendency to generate IgE has been thought to reflect the balance between type 1 and …

Stringent regulation of IgE antibody production is critical for constraining allergic responses.
This review discusses recent advances in understanding cell-intrinsic and extrinsic …

Abstract Current Adaptive Immune Receptor Repertoire sequencing (AIRR-seq) using short-
read sequencing strategies resolve expressed Ab transcripts with limited resolution of the C …

Allergies to food and environmental antigens have steeply grown to epidemic proportions.
IgE antibodies are key mediators of allergic disease, including life-threatening anaphylaxis …

Mutated and unmutated IgE and IgG play different and partly opposing roles in allergy
development, but the mechanisms controlling their relative production are incompletely …

The generation of memory B cells (MBCs) that have undergone immunoglobulin class
switching from IgM, which dominates primary antibody responses, to other immunoglobulin …

Expression of the membrane-bound form of the immunoglobulin (Ig) as part of the antigen
receptor is indispensable for both the development and the effector function of B cells …