The central dogma of gene expression is that DNA is transcribed into messenger RNAs,
which in turn serve as the template for protein synthesis. The discovery of extensive …

Methodological breakthroughs over the past four decades have repeatedly revolutionized
transcriptome profiling. Using RNA sequencing (RNA-seq), it has now become possible to …

As vertebrate genome sequences near completion and research refocuses to their analysis,
the issue of effective genome annotation display becomes critical. A mature web tool for …

▪ Abstract Alternative pre-mRNA splicing is a central mode of genetic regulation in higher
eukaryotes. Variability in splicing patterns is a major source of protein diversity from the …

▪ Abstract Systems biology studies biological systems by systematically perturbing them
(biologically, genetically, or chemically); monitoring the gene, protein, and informational …

There are many sources of systematic variation in cDNA microarray experiments which
affect the measured gene expression levels (eg differences in labeling efficiency between …

Only a small proportion of the mouse genome is transcribed into mature messenger RNA
transcripts. There is an international collaborative effort to identify all full-length mRNA …

Common human diseases result from the interplay of many genes and environmental
factors. Therefore, a more integrative biology approach is needed to unravel the complexity …

The development of electrically addressable, label-free detectors for DNA and other
biological macromolecules has the potential to impact basic biological research as well as …

Recent genome-wide analyses of alternative splicing indicate that 40–60% of human genes
have alternative splice forms, suggesting that alternative splicing is one of the most …