A review of the antiviral activity of cationic antimicrobial peptides
Viral epidemics are occurring frequently, and the COVID-19 viral pandemic has resulted in
at least 6.5 million deaths worldwide. Although antiviral therapeutics are available, these …
at least 6.5 million deaths worldwide. Although antiviral therapeutics are available, these …
HIV integrase inhibitors: 20-year landmark and challenges
M Métifiot, C Marchand, Y Pommier - Advances in pharmacology, 2013 - Elsevier
Since the discovery of HIV as the cause for AIDS 30 years ago, major progress has been
made, including the discovery of drugs that now control the disease. Here, we review the …
made, including the discovery of drugs that now control the disease. Here, we review the …
Fluorescence anisotropy: from single molecules to live cells
The polarization of light emitted by fluorescent probes is an easily accessible physical
quantity that is related to a multitude of molecular parameters including conformation …
quantity that is related to a multitude of molecular parameters including conformation …
Neuropeptides and other bioactive peptides: from discovery to function
LD Fricker - 2012 - books.google.com
Neuropeptides and peptide hormones represent the largest class of chemical messengers
that transmit information from one cell to another. In this review, several decades of research …
that transmit information from one cell to another. In this review, several decades of research …
[HTML][HTML] The HIV-1 passage from cytoplasm to nucleus: the process involving a complex exchange between the components of HIV-1 and cellular machinery to access …
KD Jayappa, Z Ao, X Yao - International journal of biochemistry …, 2012 - ncbi.nlm.nih.gov
The human immunodeficiency virus 1 (HIV-1) synthesizes its genomic DNA in cytoplasm as
soon as it enters the cell. The newly synthesized DNA remains associated with viral/cellular …
soon as it enters the cell. The newly synthesized DNA remains associated with viral/cellular …
HIV-1 IN inhibitors: 2010 update and perspectives
C Marchand, K Maddali, M Métifiot… - Current topics in …, 2009 - ingentaconnect.com
Integrase (IN) is the newest validated target against AIDS and retroviral infections. The
remarkable activity of raltegravir (Isentress®) led to its rapid approval by the FDA in 2007 as …
remarkable activity of raltegravir (Isentress®) led to its rapid approval by the FDA in 2007 as …
Allosteric modulation of protein oligomerization: an emerging approach to drug design
R Gabizon, A Friedler - Frontiers in chemistry, 2014 - frontiersin.org
Many disease-related proteins are in equilibrium between different oligomeric forms. The
regulation of this equilibrium plays a central role in maintaining the activity of these proteins …
regulation of this equilibrium plays a central role in maintaining the activity of these proteins …
[HTML][HTML] Intracellular peptides: From discovery to function
Peptidomics techniques have identified hundreds of peptides that are derived from proteins
present mainly in the cytosol, mitochondria, and/or nucleus; these are termed intracellular …
present mainly in the cytosol, mitochondria, and/or nucleus; these are termed intracellular …
Modulation of protein oligomerization: an overview
N Kumari, S Yadav - Progress in Biophysics and Molecular Biology, 2019 - Elsevier
A large section of cellular proteins in both prokaryotic and eukaryotic systems have
oligomeric property. Intently, oligomerization of protein is an invaluable phenomenon from …
oligomeric property. Intently, oligomerization of protein is an invaluable phenomenon from …
Cyclic peptide inhibitors of HIV-1 integrase derived from the LEDGF/p75 protein
Z Hayouka, M Hurevich, A Levin, H Benyamini… - Bioorganic & medicinal …, 2010 - Elsevier
Restricting linear peptides to their bioactive conformation is an attractive way of improving
their stability and activity. We used a cyclic peptide library with conformational diversity for …
their stability and activity. We used a cyclic peptide library with conformational diversity for …