Short and tall stature: a new paradigm emerges

J Baron, L Sävendahl, F De Luca, A Dauber… - Nature Reviews …, 2015 - nature.com
In the past, the growth hormone (GH)–insulin-like growth factor 1 (IGF-1) axis was often
considered to be the main system that regulated childhood growth and, therefore …

Predictors of quality of life in acromegaly: no consensus on biochemical parameters

VJ Geraedts, CD Andela, GK Stalla… - Frontiers in …, 2017 - frontiersin.org
Background Quality of life (QoL) in patients with acromegaly is reduced irrespective of
disease state. The contributions of multifactorial determinants of QoL in several disease …

[HTML][HTML] Novel genetic cause of idiopathic short stature

MJ Kang - Annals of pediatric endocrinology & metabolism, 2017 - ncbi.nlm.nih.gov
Traditionally, the growth hormone–insulin-like growth factor I (GH–IGF-I) axis is the most
important signaling pathway in linear growth, and defects in this axis present as growth …

Methods of evaluating spontaneous growth hormone secretion

K Albertsson-Wikland, S Rosberg - … of endocrine function in children and …, 2003 - karger.com
Growth hormone (GH) is secreted in pulses 24h/day [Robinson, 1991]. Because GH
secretion is pulsatile, a single measurement of GH concentrations in blood does not …

Patterns of GH output and their synchrony with short-term height increments influence stature and growth performance in normal children

MS Gill, V Tillmann, JD Veldhuis… - The Journal of Clinical …, 2001 - academic.oup.com
GH is the principal hormone driving growth throughout childhood, but the mechanism by
which changing GH secretion is translated into height (Ht) remains undefined. We previously …

Patient selection for IGF-I therapy

PE Clayton, O Ayoola, AJ Whatmore - Hormone Research in Paediatrics, 2006 - karger.com
During the late 1980s and early 1990s, considerable research effort was put into defining
pituitary GH output and possible abnormalities in 'physiological'GH secretion that could …

Persistent synchronized oscillations in prolactin gene promoter activity in living pituitary cells

DW McFerran, JA Stirland, AJ Norris, RA Khan… - …, 2001 - academic.oup.com
PRL gene expression in the anterior pituitary gland responds rapidly to different hormonal
signals. We have investigated the long-term timing of transcriptional activation from the PRL …

Leptin measurement in urine in children and its relationship to other growth peptides in serum and urine

N Zaman, CM Hall, MS Gill, J Jones… - Clinical …, 2003 - Wiley Online Library
Summary objective Leptin has been implicated in the interaction between nutrition, energy
balance and sexual maturation in humans. A non‐invasive method of measuring leptin …

Short-term growth in children with growth disorders

V Tillmann, PJ Foster, MS Gill, DAP Rice… - Annals of human …, 2002 - Taylor & Francis
Objective: We have previously demonstrated that normal prepubertal growth over 1 year is
composed of growth spurts lasting an average of 8 weeks, separated by periods of very slow …

The effect of different patterns of growth hormone administration on the IGF axis and somatic and skeletal growth of the dwarf rat

M Westwood, AR Maqsood… - American Journal …, 2010 - journals.physiology.org
Normal childhood growth is determined by ultradian and infradian variations in GH
secretion, yet GH treatment of children with short stature is restricted to daily fixed doses. We …