Short and tall stature: a new paradigm emerges
In the past, the growth hormone (GH)–insulin-like growth factor 1 (IGF-1) axis was often
considered to be the main system that regulated childhood growth and, therefore …
considered to be the main system that regulated childhood growth and, therefore …
Predictors of quality of life in acromegaly: no consensus on biochemical parameters
VJ Geraedts, CD Andela, GK Stalla… - Frontiers in …, 2017 - frontiersin.org
Background Quality of life (QoL) in patients with acromegaly is reduced irrespective of
disease state. The contributions of multifactorial determinants of QoL in several disease …
disease state. The contributions of multifactorial determinants of QoL in several disease …
[HTML][HTML] Novel genetic cause of idiopathic short stature
MJ Kang - Annals of pediatric endocrinology & metabolism, 2017 - ncbi.nlm.nih.gov
Traditionally, the growth hormone–insulin-like growth factor I (GH–IGF-I) axis is the most
important signaling pathway in linear growth, and defects in this axis present as growth …
important signaling pathway in linear growth, and defects in this axis present as growth …
Methods of evaluating spontaneous growth hormone secretion
K Albertsson-Wikland, S Rosberg - … of endocrine function in children and …, 2003 - karger.com
Growth hormone (GH) is secreted in pulses 24h/day [Robinson, 1991]. Because GH
secretion is pulsatile, a single measurement of GH concentrations in blood does not …
secretion is pulsatile, a single measurement of GH concentrations in blood does not …
Patterns of GH output and their synchrony with short-term height increments influence stature and growth performance in normal children
MS Gill, V Tillmann, JD Veldhuis… - The Journal of Clinical …, 2001 - academic.oup.com
GH is the principal hormone driving growth throughout childhood, but the mechanism by
which changing GH secretion is translated into height (Ht) remains undefined. We previously …
which changing GH secretion is translated into height (Ht) remains undefined. We previously …
Patient selection for IGF-I therapy
PE Clayton, O Ayoola, AJ Whatmore - Hormone Research in Paediatrics, 2006 - karger.com
During the late 1980s and early 1990s, considerable research effort was put into defining
pituitary GH output and possible abnormalities in 'physiological'GH secretion that could …
pituitary GH output and possible abnormalities in 'physiological'GH secretion that could …
Persistent synchronized oscillations in prolactin gene promoter activity in living pituitary cells
DW McFerran, JA Stirland, AJ Norris, RA Khan… - …, 2001 - academic.oup.com
PRL gene expression in the anterior pituitary gland responds rapidly to different hormonal
signals. We have investigated the long-term timing of transcriptional activation from the PRL …
signals. We have investigated the long-term timing of transcriptional activation from the PRL …
Leptin measurement in urine in children and its relationship to other growth peptides in serum and urine
N Zaman, CM Hall, MS Gill, J Jones… - Clinical …, 2003 - Wiley Online Library
Summary objective Leptin has been implicated in the interaction between nutrition, energy
balance and sexual maturation in humans. A non‐invasive method of measuring leptin …
balance and sexual maturation in humans. A non‐invasive method of measuring leptin …
Short-term growth in children with growth disorders
V Tillmann, PJ Foster, MS Gill, DAP Rice… - Annals of human …, 2002 - Taylor & Francis
Objective: We have previously demonstrated that normal prepubertal growth over 1 year is
composed of growth spurts lasting an average of 8 weeks, separated by periods of very slow …
composed of growth spurts lasting an average of 8 weeks, separated by periods of very slow …
The effect of different patterns of growth hormone administration on the IGF axis and somatic and skeletal growth of the dwarf rat
M Westwood, AR Maqsood… - American Journal …, 2010 - journals.physiology.org
Normal childhood growth is determined by ultradian and infradian variations in GH
secretion, yet GH treatment of children with short stature is restricted to daily fixed doses. We …
secretion, yet GH treatment of children with short stature is restricted to daily fixed doses. We …