Epigenetic modifications play a vital role in the preservation of genome integrity and in the
regulation of gene expression. DNA methylation, one of the key mechanisms of epigenetic …

DNA damage response (DDR) in eukaryotic cells is initiated in the chromatin context. DNA
damage and repair depend on or have influence on the chromatin dynamics associated with …

The nonmethylable cytosine analogs, 5-azacytidine and zebularine, are widely used to
inhibit DNA methyltransferase activity and reduce genomic DNA methylation. In this study …

Homologous recombination repair (HR) is an error-free DNA damage repair pathway to
maintain genome stability and a basis of gene targeting using genome-editing tools …

Epigenetic variation has been proposed to contribute to the success of asexual plants, either
as a contributor to phenotypic plasticity or by enabling transient adaptation via selection on …

Background The mobilization of transposable elements (TEs) is suppressed by host genome
defense mechanisms. Recent studies showed that the cis-regulatory region of Arabidopsis …

Eukaryotic genomes contain a vast diversity of transposable elements (TEs). Formerly often
described as selfish and parasitic DNA sequences, TEs are now recognised as a source of …

Many plants are facultatively asexual, balancing short-term benefits with long-term costs of
asexuality. During range expansion, natural selection likely influences the genetic controls …

DNA–protein cross-links (DPCs) are highly toxic DNA lesions consisting of proteins
covalently attached to chromosomal DNA. Unrepaired DPCs physically block DNA …

Retinoblastoma (pRb) is a multifunctional regulator, which was likely present in the last
common ancestor of all eukaryotes. The Arabidopsis pRb homolog RETINOBLASTOMA …