Abstract Vitamin B12 (cobalamin, Cbl) is a nutrient essential to human health. Due to its
complex structure and dual cofactor forms, Cbl undergoes a complicated series of …

Metabolism of excess methionine (Met) to homocysteine (Hcy) by transmethylation is
facilitated by the expression of methionine adenosyltransferase (MAT) I/III and glycine N …

Most rare clinical missense variants cannot currently be classified as pathogenic or benign.
Deficiency in human 5, 10-methylenetetrahydrofolate reductase (MTHFR), the most common …

Vitamin B micronutrients are essential regulators of one carbon metabolism that ensures
human health. Vitamin B9, or folate, lies at the heart of the folate cycle and converges with …

Metabolic reprogramming is a key hallmark of cancer and shifts cellular metabolism to meet
the demands of biomass production necessary for abnormal cell reproduction. One-carbon …

S-adenosylmethionine (SAM) is essential for methyl transfer reactions. All SAM is produced
de novo via the methionine cycle. The demethylation of SAM produces S …

Aims: Hyperhomocysteinemia (HHcy) has been considered as a risk factor for
cardiovascular disease, Alzheimer's disease, nonalcoholic fatty liver, and many other …

Ethnopharmacological relevance Ginkgo biloba L. is a rare tree species unique to China.
Ginkgo biloba is a traditional Chinese medicinal with a long history, acting on the heart and …

Early onset schizophrenia (EOS, defined as first onset of schizophrenia before age 18) is a
rare form of schizophrenia (SCZ). Though genome-wide association studies (GWASs) have …

Methylenetetrahydrofolate reductase (MTHFR) links the folate cycle to the methionine cycle
in one-carbon metabolism. The enzyme is known to be allosterically inhibited by SAM for …