Abstract The International Molecular Exchange (IMEx) consortium is an international
collaboration between major public interaction data providers to share literature-curation …

Today, it is widely appreciated that protein–protein interactions play a fundamental role in
biological processes. This was not always the case. The study of protein interactions started …

Global insights into cellular organization and genome function require comprehensive
understanding of the interactome networks that mediate genotype–phenotype relationships …

We provide an overview of recent developments in big data analyses in the context of
precision medicine and health informatics. With the advance in technologies capturing …

Efforts to map the Escherichia coli interactome have identified several hundred
macromolecular complexes, but direct binary protein-protein interactions (PPIs) have not …

Cellular functions are mediated by complex interactome networks of physical, biochemical,
and functional interactions between DNA sequences, RNA molecules, proteins, lipids, and …

The yeast two-hybrid system pioneered the field of in vivo protein-protein interaction
methods and undisputedly gave rise to a palette of ingenious techniques that are constantly …

To uncover shared pathogenic mechanisms among the highly heterogeneous autism
spectrum disorders (ASDs), we developed a protein interaction network that identified …

The analysis of protein interaction networks is one of the key challenges in the study of
biology. It connects genotypes to phenotypes, and disruption often leads to diseases …

The sesquiterpenoid abscisic acid (ABA) mediates an assortment of responses across a
variety of kingdoms including both higher plants and animals. In plants, where most is …