[HTML][HTML] Knocking down barriers: advances in siRNA delivery
In the 10 years that have passed since the Nobel prize-winning discovery of RNA
interference (RNAi), billions of dollars have been invested in the therapeutic application of …
interference (RNAi), billions of dollars have been invested in the therapeutic application of …
siRNA vs. shRNA: similarities and differences
DD Rao, JS Vorhies, N Senzer, J Nemunaitis - Advanced drug delivery …, 2009 - Elsevier
RNA interference (RNAi) is a natural process through which expression of a targeted gene
can be knocked down with high specificity and selectivity. Using available technology and …
can be knocked down with high specificity and selectivity. Using available technology and …
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
A Akinc, A Zumbuehl, M Goldberg, ES Leshchiner… - Nature …, 2008 - nature.com
The safe and effective delivery of RNA interference (RNAi) therapeutics remains an
important challenge for clinical development. The diversity of current delivery materials …
important challenge for clinical development. The diversity of current delivery materials …
[HTML][HTML] Interfering with disease: a progress report on siRNA-based therapeutics
A de Fougerolles, HP Vornlocher… - Nature reviews Drug …, 2007 - nature.com
RNA interference (RNAi) quietly crept into biological research in the 1990s when
unexpected gene-silencing phenomena in plants and flatworms first perplexed scientists …
unexpected gene-silencing phenomena in plants and flatworms first perplexed scientists …
[HTML][HTML] RNAi therapeutics: a potential new class of pharmaceutical drugs
D Bumcrot, M Manoharan, V Koteliansky… - Nature chemical …, 2006 - nature.com
The rapid identification of highly specific and potent drug candidates continues to be a
substantial challenge with traditional pharmaceutical approaches. Moreover, many targets …
substantial challenge with traditional pharmaceutical approaches. Moreover, many targets …
RNAi therapeutics: principles, prospects and challenges
RNA interference (RNAi) was discovered less than a decade ago and already there are
human clinical trials in progress or planned. A major advantage of RNAi versus other …
human clinical trials in progress or planned. A major advantage of RNAi versus other …
siRNA delivery systems for cancer treatment
YK Oh, TG Park - Advanced drug delivery reviews, 2009 - Elsevier
With increasing knowledge on the molecular mechanisms of endogenous RNA interference,
small interfering RNAs (siRNAs) have been emerging as innovative nucleic acid medicines …
small interfering RNAs (siRNAs) have been emerging as innovative nucleic acid medicines …
Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells
H Tazawa, N Tsuchiya, M Izumiya… - Proceedings of the …, 2007 - National Acad Sciences
Accumulating evidence suggests a role for microRNAs in human carcinogenesis as novel
types of tumor suppressors or oncogenes. However, their precise biological role remains …
types of tumor suppressors or oncogenes. However, their precise biological role remains …
Employing siRNA tool and its delivery platforms in suppressing cisplatin resistance: approaching to a new era of cancer chemotherapy
Although chemotherapy is a first option in treatment of cancer patients, drug resistance has
led to its failure, requiring strategies to overcome it. Cancer cells are capable of switching …
led to its failure, requiring strategies to overcome it. Cancer cells are capable of switching …
Cancer siRNA therapy by tumor selective delivery with ligand-targeted sterically stabilized nanoparticle
RM Schiffelers, A Ansari, J Xu, Q Zhou… - Nucleic acids …, 2004 - academic.oup.com
Potent sequence selective gene inhibition by siRNA 'targeted'therapeutics promises the
ultimate level of specificity, but siRNA therapeutics is hindered by poor intracellular uptake …
ultimate level of specificity, but siRNA therapeutics is hindered by poor intracellular uptake …