Leishmaniasis–current chemotherapy and recent advances in the search for novel drugs
SL Croft, GH Coombs - Trends in parasitology, 2003 - cell.com
The chemotherapy currently available for leishmaniasis is far from satisfactory. Resistance to
the pentavalent antimonials, which have been the recommended drugs for the treatment of …
the pentavalent antimonials, which have been the recommended drugs for the treatment of …
Subversion Mechanisms by Which Leishmania Parasites Can Escape the Host Immune Response: a Signaling Point of View
M Olivier, DJ Gregory, G Forget - Clinical microbiology reviews, 2005 - Am Soc Microbiol
The obligate intracellular parasite Leishmania must survive the antimicrobial activities of its
host cell, the macrophage, and prevent activation of an effective immune response. In order …
host cell, the macrophage, and prevent activation of an effective immune response. In order …
Mechanisms of immune evasion in leishmaniasis
G Gupta, S Oghumu, AR Satoskar - Advances in applied microbiology, 2013 - Elsevier
Diseases caused by Leishmania present a worldwide problem, and current therapeutic
approaches are unable to achieve a sterile cure. Leishmania is able to persist in host cells …
approaches are unable to achieve a sterile cure. Leishmania is able to persist in host cells …
[PDF][PDF] Immune response to Leishmania infection
Leishmania is a protozoan parasite and the causative agent of the disease leishmaniasis.
Anti-leishmanial immune response is shown to be host genotype dependent so that some …
Anti-leishmanial immune response is shown to be host genotype dependent so that some …
Reciprocal CD40 signals through p38MAPK and ERK-1/2 induce counteracting immune responses
Macrophages play host to Leishmania major, a parasite that causes leishmaniasis in
500,000 people annually. Macrophage-expressed CD40, a costimulatory molecule, induces …
500,000 people annually. Macrophage-expressed CD40, a costimulatory molecule, induces …
The pathogenicity and virulence of Leishmania-interplay of virulence factors with host defenses
Leishmaniasis is a group of disease caused by the intracellular protozoan parasite of the
genus Leishmania. Infection by different species of Leishmania results in various host …
genus Leishmania. Infection by different species of Leishmania results in various host …
Sodium antimony gluconate induces generation of reactive oxygen species and nitric oxide via phosphoinositide 3-kinase and mitogen-activated protein kinase …
Pentavalent antimony complexes, such as sodium stibogluconate and sodium antimony
gluconate (SAG), are still the first choice for chemotherapy against various forms of …
gluconate (SAG), are still the first choice for chemotherapy against various forms of …
[HTML][HTML] Leishmania Spp-Host Interaction: There Is Always an Onset, but Is There an End?
F Conceição-Silva, FN Morgado - Frontiers in cellular and infection …, 2019 - frontiersin.org
For a long time Leishmaniasis had been considered as a neglected tropical disease.
Recently, it has become a priority in public health all over the world for different aspects such …
Recently, it has become a priority in public health all over the world for different aspects such …
Miltefosine promotes IFN-γ-dominated anti-leishmanial immune response
P Wadhone, M Maiti, R Agarwal, V Kamat… - The journal of …, 2009 - journals.aai.org
Leishmania donovani, a protozoan parasite, resides and replicates as amastigotes within
macrophages. The parasite inflicts the disease visceral leishmaniasis by suppressing host …
macrophages. The parasite inflicts the disease visceral leishmaniasis by suppressing host …
[HTML][HTML] The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivation
The Leishmania parasite is a widespread disease threat in tropical areas, causing
symptoms ranging from skin lesions to death. Leishmania parasites typically invade …
symptoms ranging from skin lesions to death. Leishmania parasites typically invade …