During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome
stability by delaying cell division until accurate chromosome segregation can be …

In eukaryotes, chromosome segregation during cell division is facilitated by the kinetochore,
a multiprotein structure that is assembled on centromeric DNA. The kinetochore attaches …

Mistakes during cell division frequently generate changes in chromosome content,
producing aneuploid or polyploid progeny cells. Polyploid cells may then undergo abnormal …

The appropriate timing of events that lead to chromosome segregation during mitosis and
cytokinesis is essential to prevent aneuploidy, and defects in these processes can contribute …

Chromosome congression during prometaphase culminates with the establishment of a
metaphase plate, a hallmark of mitosis in metazoans. Classical views resulting from more …

The anaphase-promoting complex or cyclosome (APC/C) is a conserved, multisubunit E3
ubiquitin (Ub) ligase that is active both in dividing and in postmitotic cells. Its contributions to …

The mitotic spindle assembly checkpoint (SAC) delays anaphase onset until all
chromosomes have attached to both spindle poles,. Here, we investigated SAC signalling …

Mitotic spindle bipolarity is essential for faithful segregation of chromosomes during cell
division. Multipolar spindles are often seen in human cancers and are usually associated …

A common assumption is that human chromosomes carry equal chances of mis-segregation
during compromised cell division. Human chromosomes vary in multiple parameters that …

Chromosome alignment to the spindle equator is a hallmark of mitosis thought to promote
chromosome segregation fidelity in metazoans. Yet chromosome alignment is only indirectly …