Objective/background Acute myeloid leukemia (AML) is defined as leukemic blast
reproduction in bone marrow. Chromosomal abnormalities form different subgroups with …

Introduction: Since the first fusion gene was discovered decades ago, a considerable
number of fusion genes have been detected in leukemia. The majority of them are …

The role of autophagy during leukemia treatment is unclear. On the one hand, autophagy
might be induced as a prosurvival response to therapy, thereby reducing treatment …

Abstract Purpose: KIT mutations (KIT+) are common in core binding factor (CBF) AML and
have been associated with varying prognostic significance. We sought to define the …

The prognostic significance of KIT mutations in core-binding factor acute myeloid leukemia
(CBF-AML), including inv (16) and t (8; 21) AML, is uncertain. We performed a systematic …

Acute myeloid leukemia (AML) is a complex disease caused by deregulation of multiple
signaling pathways. Mutations in class III receptor tyrosine kinases (RTKs) have been …

Although allogeneic hematopoietic cell transplantation (allo-HCT) remains the backbone of
curative treatment for the majority of fit adults diagnosed with AML, there is indeed a subset …

In core-binding factor acute myeloid leukemia (CBF-AML), there have been conflicting
reports regarding the status as an unfavorable prognostic factor of mutation in the KIT gene …

Comprehensive genomic profiling examinations (CGPs) have recently been developed, and
a variety of tumor-agnostic mutations have been detected, leading to the development of …

The prevalence and clinical relevance of KIT mutations in childhood core-binding factor
(CBF) acute myeloid leukemia (AML) have not been well characterized. In this study, a total …