Studies of metal uptake, metabolism and excretion by single bacterial, yeast, plant and
animal cells is a widespread area of research, yet little is known about the reactivity and …

Covering: 1907 to 2006This article reviews the curious history of kojic acid, discovered as a
fungal natural product in 1907. It was one of the first secondary metabolites to have its …

The discovery of vanadium's insulin-like behaviour in vitro, and later of the orally available
glucose-and lipid-lowering capability of these same compounds in vivo, has stimulated …

The family of hydroxypyrones and close congeners, the hydroxypyridinones, is a particularly
versatile class of ligands. The most widely investigated for medicinal applications are the 3 …

A series of 2-alkyl-3-hydroxy-4-pyrone oxovanadium (IV) compounds has been synthesized,
characterized, and tested for bioactivity as potential insulin-enhancing agents. The vanadyl …

Simple, high-yield, large-scale syntheses of the V (III) complexes tris (maltolato) vanadium
(III), V (ma) 3, tris (ethylmaltolato) vanadium (III), V (ema) 3, tris (kojato) vanadium (III) …

The current status and likely future directions of complexes of V (V/IV), Cr (III), Mo (VI), W (VI),
Zn (II), Cu (II), and Mn (III) as potential oral drugs against type 2 diabetes are reviewed. We …

A wide variety of vanadium-containing complexes have been tested, both in vivo and in vitro,
as possible therapeutic agents for the oral treatment of type 2 diabetes mellitus. None so far …

222 223 223 224 225 3. VANADIUM COMPOUNDS AS INSULIN MIMETIC AGENTS 226
3.1. History: In vitro and in vivo Insulin-like Effects of the Vanadium Salts Vanadate (VO) and …

Vanadium compounds, in vitro, stimulate glucose uptake and inhibit lipid breakdown, in a
manner remarkably reminiscent of insulin's effects. In vivo, vanadium enhances insulin's …