Machine perfusion of the liver and bioengineering

A Schlegel, H Mergental, C Fondevila, RJ Porte… - Journal of …, 2023 - Elsevier
With the increasing number of accepted candidates on waiting lists worldwide, there is an
urgent need to expand the number and the quality of donor livers. Dynamic preservation …

[HTML][HTML] Transplant oncology–Current indications and strategies to advance the field

FJ Krendl, R Bellotti, G Sapisochin, B Schaefer, H Tilg… - JHEP Reports, 2024 - Elsevier
Liver transplantation (LT) was originally described by Starzl as a promising strategy to treat
primary malignancies of the liver. Confronted with high recurrence rates, indications drifted …

[HTML][HTML] A multicenter randomized-controlled trial of hypothermic oxygenated perfusion (HOPE) for human liver grafts before transplantation

A Schlegel, M Mueller, X Muller, J Eden… - Journal of …, 2023 - Elsevier
Background & Aims Machine perfusion is a novel method intended to optimize livers before
transplantation. However, its effect on morbidity within a 1-year period after transplantation …

Machine perfusion techniques for liver transplantation-A meta-analysis of the first seven randomized-controlled trials

A Parente, F Tirotta, A Pini, J Eden, D Dondossola… - Journal of …, 2023 - Elsevier
Background & Aims Machine perfusion is increasingly being tested in clinical
transplantation. Despite this, the number of large prospective clinical trials remains limited …

[HTML][HTML] Utilization of livers donated after circulatory death for transplantation–An international comparison

J Eden, RXS Da Silva, M Cortes-Cerisuelo… - Journal of …, 2023 - Elsevier
Background & Aims Liver graft utilization rates are a hot topic due to the worldwide organ
shortage and the increasing number of transplant candidates on waiting lists. Liver perfusion …

Bile proteome reveals biliary regeneration during normothermic preservation of human donor livers

AM Thorne, JC Wolters, B Lascaris… - Nature …, 2023 - nature.com
Normothermic machine perfusion (NMP) after static cold storage is increasingly used for
preservation and assessment of human donor livers prior to transplantation. Biliary viability …

Screening for mitochondrial function before use-routine liver assessment during hypothermic oxygenated perfusion impacts liver utilization

J Eden, E Breuer, D Birrer, M Müller, M Pfister… - …, 2023 - thelancet.com
Background To report on a concept of liver assessment during ex situ hypothermic
oxygenated perfusion (HOPE) and its significant impact on liver utilization. Methods An …

Viability testing during liver preservation

D Patrono, C Lonati, R Romagnoli - Current Opinion in Organ …, 2022 - journals.lww.com
MP adds a further element of complexity in the process of assessing the quality of a liver
graft. Understanding the physiology of the parameters included in the different assessment …

Viability assessment and transplantation of fatty liver grafts using end‐ischemic normothermic machine perfusion

D Patrono, R De Carlis, A Gambella… - Liver …, 2023 - journals.lww.com
End‐ischemic viability testing by normothermic machine perfusion (NMP) represents an
effective strategy to recover liver grafts having initially been discarded for liver …

[HTML][HTML] Long-term outcomes after hypothermic oxygenated machine perfusion and transplantation of 1,202 donor livers in a real-world setting (HOPE-REAL study)

J Eden, IMA Brüggenwirth, G Berlakovich… - Journal of …, 2025 - Elsevier
Background & Aims Despite strong evidence for improved preservation of donor livers by
machine perfusion, longer post-transplant follow-up data are urgently needed in an …