Machine perfusion of the liver and bioengineering
With the increasing number of accepted candidates on waiting lists worldwide, there is an
urgent need to expand the number and the quality of donor livers. Dynamic preservation …
urgent need to expand the number and the quality of donor livers. Dynamic preservation …
[HTML][HTML] Transplant oncology–Current indications and strategies to advance the field
Liver transplantation (LT) was originally described by Starzl as a promising strategy to treat
primary malignancies of the liver. Confronted with high recurrence rates, indications drifted …
primary malignancies of the liver. Confronted with high recurrence rates, indications drifted …
[HTML][HTML] A multicenter randomized-controlled trial of hypothermic oxygenated perfusion (HOPE) for human liver grafts before transplantation
A Schlegel, M Mueller, X Muller, J Eden… - Journal of …, 2023 - Elsevier
Background & Aims Machine perfusion is a novel method intended to optimize livers before
transplantation. However, its effect on morbidity within a 1-year period after transplantation …
transplantation. However, its effect on morbidity within a 1-year period after transplantation …
Machine perfusion techniques for liver transplantation-A meta-analysis of the first seven randomized-controlled trials
Background & Aims Machine perfusion is increasingly being tested in clinical
transplantation. Despite this, the number of large prospective clinical trials remains limited …
transplantation. Despite this, the number of large prospective clinical trials remains limited …
[HTML][HTML] Utilization of livers donated after circulatory death for transplantation–An international comparison
J Eden, RXS Da Silva, M Cortes-Cerisuelo… - Journal of …, 2023 - Elsevier
Background & Aims Liver graft utilization rates are a hot topic due to the worldwide organ
shortage and the increasing number of transplant candidates on waiting lists. Liver perfusion …
shortage and the increasing number of transplant candidates on waiting lists. Liver perfusion …
Bile proteome reveals biliary regeneration during normothermic preservation of human donor livers
AM Thorne, JC Wolters, B Lascaris… - Nature …, 2023 - nature.com
Normothermic machine perfusion (NMP) after static cold storage is increasingly used for
preservation and assessment of human donor livers prior to transplantation. Biliary viability …
preservation and assessment of human donor livers prior to transplantation. Biliary viability …
Screening for mitochondrial function before use-routine liver assessment during hypothermic oxygenated perfusion impacts liver utilization
J Eden, E Breuer, D Birrer, M Müller, M Pfister… - …, 2023 - thelancet.com
Background To report on a concept of liver assessment during ex situ hypothermic
oxygenated perfusion (HOPE) and its significant impact on liver utilization. Methods An …
oxygenated perfusion (HOPE) and its significant impact on liver utilization. Methods An …
Viability testing during liver preservation
MP adds a further element of complexity in the process of assessing the quality of a liver
graft. Understanding the physiology of the parameters included in the different assessment …
graft. Understanding the physiology of the parameters included in the different assessment …
Viability assessment and transplantation of fatty liver grafts using end‐ischemic normothermic machine perfusion
D Patrono, R De Carlis, A Gambella… - Liver …, 2023 - journals.lww.com
End‐ischemic viability testing by normothermic machine perfusion (NMP) represents an
effective strategy to recover liver grafts having initially been discarded for liver …
effective strategy to recover liver grafts having initially been discarded for liver …
[HTML][HTML] Long-term outcomes after hypothermic oxygenated machine perfusion and transplantation of 1,202 donor livers in a real-world setting (HOPE-REAL study)
J Eden, IMA Brüggenwirth, G Berlakovich… - Journal of …, 2025 - Elsevier
Background & Aims Despite strong evidence for improved preservation of donor livers by
machine perfusion, longer post-transplant follow-up data are urgently needed in an …
machine perfusion, longer post-transplant follow-up data are urgently needed in an …