The role of nitroreductases in resistance to nitroimidazoles
C Thomas, CD Gwenin - Biology, 2021 - mdpi.com
Simple Summary Antimicrobial resistance continues to be a major global health threat. It is
estimated by the WHO that 700,000 people die each year because of drug resistance, and …
estimated by the WHO that 700,000 people die each year because of drug resistance, and …
Quantum dots and gold nanoparticles as scaffolds for enzymatic enhancement: recent advances and the influence of nanoparticle size
Nanoparticle scaffolds can impart multiple benefits onto immobilized enzymes including
enhanced stability, activity, and recoverability. The magnitude of these benefits is modulated …
enhanced stability, activity, and recoverability. The magnitude of these benefits is modulated …
Gold nanoparticle templating increases the catalytic rate of an amylase, maltase, and glucokinase multienzyme cascade through substrate channeling independent of …
The templating of enzymes has shown myriad advantages, including increased stability and
kinetic rates. Specifically, the use of nanoparticles (NPs) as templates has been shown to …
kinetic rates. Specifically, the use of nanoparticles (NPs) as templates has been shown to …
Enhancing enzymatic activity with nanoparticle display–an updated compendium and engineering outlook
Almost all utilization of biocatalysis in the burgeoning field of synthetic biology requires not
only enzymes but also that they function with peak efficiency, especially when paired with …
only enzymes but also that they function with peak efficiency, especially when paired with …
A novel electrochemical sensor based on Fe3+-curcumin/multi-walled carbon nanotubes complex enabling electrochemical sensing of hydroxylamine
W Xi, Z Kong, Z Deng, Y Chen, H Mou, Y Zhang… - Diamond and Related …, 2024 - Elsevier
This work reported a novel electrocatalyst, Fe 3+-curcumin/multi-walled carbon nanotubes
(MWCNTs) complex, for efficient detection of hydroxylamine by modifying the glassy carbon …
(MWCNTs) complex, for efficient detection of hydroxylamine by modifying the glassy carbon …
Cell-penetrating peptides as a tool for the cellular uptake of a genetically modified nitroreductase for use in directed enzyme prodrug therapy
Directed enzyme prodrug therapy (DEPT) involves the delivery of a prodrug-activating
enzyme to a solid tumour site, followed by the subsequent activation of an administered …
enzyme to a solid tumour site, followed by the subsequent activation of an administered …
The dinitrobenzamide mustard prodrugs, PR-104A and SN27686, for use in a novel MNDEPT cancer prodrug therapy approach
Directed enzyme prodrug therapy is a highly promising anti-cancer strategy. However, the
current technology is limited by inefficient prodrug activation and the dose-limiting toxicity …
current technology is limited by inefficient prodrug activation and the dose-limiting toxicity …
Evaluation of two xenobiotic reductases from Pseudomonas putida for their suitability for magnetic nanoparticle‐directed enzyme prodrug therapy as a novel …
P Ball, J Halliwell, S Anderson, V Gwenin… - …, 2020 - Wiley Online Library
Directed enzyme prodrug therapy (DEPT) is a cancer chemotherapy strategy in which
bacterial enzymes are delivered to a cancer site before prodrug administration, resulting in …
bacterial enzymes are delivered to a cancer site before prodrug administration, resulting in …
The YfkO nitroreductase from bacillus licheniformis on gold-coated superparamagnetic nanoparticles: towards a novel directed enzyme prodrug therapy approach
The bacterial nitroreductase NfnB has been the focus of a great deal of research for its use
in directed enzyme prodrug therapy in combination with the nitroreductase prodrug CB1954 …
in directed enzyme prodrug therapy in combination with the nitroreductase prodrug CB1954 …
Design and development of small molecule tags and pro-tags for universal CAR T cells in cancer therapy
LK Kok - 2023 - ourarchive.otago.ac.nz
Cancer remains a major health issue in NZ and worldwide. Conventional treatments such as
surgery, radiation and chemotherapy have limited ability to treat cancers and cause …
surgery, radiation and chemotherapy have limited ability to treat cancers and cause …