The neurobiology of schizophrenia involves multiple facets of pathophysiology, ranging from
its genetic basis over changes in neurochemistry and neurophysiology, to the systemic level …

For the past decade, ketamine, an N-methyl-D-aspartate receptor (NMDAr) antagonist, has
been considered a promising treatment for major depressive disorder (MDD). Unlike the …

Ketamine is a dissociative anesthetic drug, which has more recently emerged as a rapid-
acting antidepressant. When acutely administered at subanesthetic doses, ketamine causes …

The synaptic balance between excitation and inhibition (E/I balance) is a fundamental
principle of cortical circuits, and disruptions in E/I balance are commonly linked to cognitive …

Coordinated shifts of neuronal activity in the prefrontal cortex are associated with strategy
adaptations in behavioural tasks, when animals switch from following one rule to another …

Major depressive disorder (MDD) remains a huge personal and societal encumbrance.
Particularly burdensome is a virulent subtype of MDD, treatment resistant major depression …

Alterations in neuromodulation or synaptic transmission in biophysical attractor network
models, as proposed by the dominant dopaminergic and glutamatergic theories of …

We employed multi-electrode array recording to evaluate the influence of NMDA receptors
(NMDAR) on spike-timing dynamics in prefrontal networks of monkeys as they performed a …

GABAergic and glutamatergic dysfunction in the dorsolateral prefrontal cortex (DLPFC) are
thought to be the core pathophysiological mechanisms of schizophrenia. Recently, we have …

The chief undertaking in the studies of consciousness is that of unravelling the neural
correlates of consciousness. To this day, this crusade remains at an impasse, with a clash of …