Sialic acids are a diverse family of monosaccharides widely expressed on all cell surfaces of
vertebrates and so‐called “higher” invertebrates, and on certain bacteria that interact with …

Gram-positive organisms, including the pathogens Staphylococcus aureus, Streptococcus
pneumoniae, and Enterococcus faecalis, have dynamic cell envelopes that mediate …

Many important interactions between bacterial pathogens and their hosts are highly specific
binding events that involve host or pathogen carbohydrate structures (glycans). Glycan …

Cell surfaces in the immune system are richly equipped with a complex mixture of glycans,
which can be recognized by diverse glycan-binding proteins. The Siglecs are a family of …

The surfaces of all vertebrate cells are decorated with a dense and complex array of sugar
chains, which are mostly attached to proteins and lipids. Most soluble secreted proteins are …

Streptococci readily colonize mucosal tissues in the nasopharynx; the respiratory,
gastrointestinal, and genitourinary tracts; and the skin. Each ecological niche presents a …

The wide occurrence of sialic acids (Sia) in various chemical forms linked as monomers or
polymers in an outstanding position in a multitude of complex carbohydrates of animals and …

All cells in nature are covered by a dense and complex array of carbohydrates. Given their
prominence on cell surfaces, it is not surprising that these glycans mediate and/or modulate …

Group B streptococcus (GBS) or Streptococcus agalactiae is a β-hemolytic, Gram-positive
bacterium that is a leading cause of neonatal infections. GBS commonly colonizes the lower …

Sialic acid–binding Ig-like lectins, or Siglecs, vary in their specificity for sialic acid–
containing ligands and are mainly expressed by cells of the immune system. Many Siglecs …