Biocatalytic cascades are a powerful tool for building complex molecules containing oxygen
and nitrogen functionalities. Moreover, the combination of multiple enzymes in one pot offers …

Metagenomic sequencing data provide a rich resource from which to expand our
understanding of differential protein functions involved in human health. Here, we outline a …

Biotransformation plays a crucial role in regulating the bioaccumulation potential and toxicity
of organic compounds in organisms but is, in general, poorly understood for emerging …

Benzylisoquinoline alkaloid derived pharmaceuticals are widely applied in modern
medicines. Recent studies on the microbial production of benzylisoquinolines have …

Methyltransferases (MTases) play an important role in the functioning of living systems,
catalyzing the methylation reactions of DNA, RNA, proteins, and small molecules, including …

The tetrahydroisoquinoline (THIQ) ring system is present in a large variety of structurally
diverse natural products exhibiting a wide range of biological activities. Routes to mimic the …

The engineered de novo vanillin biosynthesis pathway constructed in Escherichia coli is
industrially relevant but limited by the reaction catalyzed by catechol O-methyltransferase …

Background The efficient depolymerization and utilization of lignin are one of the most
important goals for the renewable use of lignocelluloses. The degradation and complete …

S-Adenosyl-l-methionine (SAM)-mediated methylation of biomolecules controls their
function and regulates numerous vital intracellular processes. Analogs of SAM with a …

O-methyltransferases (OMTs) have been demonstrated to play key roles in the biosynthesis
of plant secondary metabolites, such as alkaloids, isoprenoids, and phenolic compounds …