BEACH domain proteins function as cargo-sorting adaptors in secretory and endocytic pathways
S Pankiv, AK Dahl, A Aas, RL Andersen, A Brech… - Journal of Cell …, 2024 - rupress.org
We identify BEACH domain–containing proteins (BDCPs) as novel membrane coat proteins
involved in the sorting of transmembrane proteins (TMPs) on the trans-Golgi network and …
involved in the sorting of transmembrane proteins (TMPs) on the trans-Golgi network and …
[HTML][HTML] Macrophage WDFY3, a protector against autoimmunity
Efficient efferocytosis is essential for maintaining homeostasis. Excessive apoptotic cell (AC)
death and impaired macrophage efferocytosis lead to autoantigen release and autoantibody …
death and impaired macrophage efferocytosis lead to autoantigen release and autoantibody …
Drosophila Bchs overexpression recapitulates human WDFY3 neurodevelopmental phenotypes with implications for glial cell involvement in altered head …
MB Körner, A Velluva, L Bundalian, K Krohn, K Schön… - bioRxiv, 2023 - biorxiv.org
The autophagy adaptor WDFY3 is linked to neurodevelopmental delay and altered brain
size. Loss-of-function variants are associated with an increased brain size in both humans …
size. Loss-of-function variants are associated with an increased brain size in both humans …