Recent gene expression profiling of breast cancer has identified specific subtypes with
clinical, biologic, and therapeutic implications. The basal-like group of tumors is …

DNA methylation is not just for basic scientists any more. There is a growing awareness in
the medical field that having the correct pattern of genomic methylation is essential for …

Accurately identifying patients with high-grade serous ovarian carcinoma (HGSOC) who
respond to poly (ADP-ribose) polymerase inhibitor (PARPi) therapy is of great clinical …

Background: Inherited mutations in the BRCA1 gene may be responsible for almost half of
inherited breast carcinomas. However, somatic (acquired) mutations in BRCA1 have not …

Hypermethylation of CpG islands in the promoter regions is an important mechanism to
silence the expression of many important genes in cancer. The hypermethylation status is …

DNA methylation is an epigenetic modification involved in both normal developmental
processes and disease states through the modulation of gene expression and the …

Epigenetic mechanisms act to change the accessibility of chromatin to transcriptional
regulation locally and globally via modifications of the DNA and by modification or …

During the last decade, gene expression profiling of breast cancer has revealed the
existence of five molecular subtypes and allowed the establishment of a new classification …

Both genetic and epigenetic changes contribute to development of human cancer.
Oncogenomics has primarily focused on understanding the genetic basis of neoplasia, with …

Germline mutations of BRCA1 predispose women to breast and ovarian cancers. BRCA1
contains several functional domains that interact directly or indirectly with a variety of …