Lipids and lipid derivatives for RNA delivery

Y Zhang, C Sun, C Wang, KE Jankovic… - Chemical reviews, 2021 - ACS Publications
RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …

Tetrazoles via multicomponent reactions

CG Neochoritis, T Zhao, A Domling - Chemical reviews, 2019 - ACS Publications
Tetrazole derivatives are a prime class of heterocycles, very important to medicinal
chemistry and drug design due to not only their bioisosterism to carboxylic acid and amide …

Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation

L Miao, L Li, Y Huang, D Delcassian, J Chahal… - Nature …, 2019 - nature.com
Therapeutic messenger RNA vaccines enable delivery of whole antigens, which can be
advantageous over peptide vaccines. However, optimal efficacy requires both intracellular …

Hydroxyapatite: A review of syntheses, structure and applications in heterogeneous catalysis

A Fihri, C Len, RS Varma, A Solhy - Coordination Chemistry Reviews, 2017 - Elsevier
The synthesis of hydroxyapatite (HAP) and its applications in heterogeneous catalysis are
abridged in view of its demonstrated prowess and utility in chemical, material and industrial …

Consecutive multicomponent reactions for the synthesis of complex molecules

S Zhi, X Ma, W Zhang - Organic & Biomolecular Chemistry, 2019 - pubs.rsc.org
Multicomponent reactions (MCRs) involving a minimum of three reactants or reaction
centers are conducted in one pot and with a single operational step. This synthetic method …

Silver nanoparticles-decorated Preyssler functionalized cellulose biocomposite as a novel and efficient catalyst for the synthesis of 2-amino-4H-pyrans and …

S Saneinezhad, L Mohammadi, V Zadsirjan… - Scientific reports, 2020 - nature.com
Silver nanoparticles-decorated Preyssler functionalized cellulose biocomposite (PC/AgNPs)
was prepared and fully characterized by FTIR, UV–vis, SEM, and TEM techniques. The …

Recent applications of the multicomponent synthesis for bioactive pyrazole derivatives

D Becerra, R Abonia, JC Castillo - Molecules, 2022 - mdpi.com
Pyrazole and its derivatives are considered a privileged N-heterocycle with immense
therapeutic potential. Over the last few decades, the pot, atom, and step economy (PASE) …

To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis

M Giustiniano, A Basso, V Mercalli… - Chemical Society …, 2017 - pubs.rsc.org
The term functionalized isocyanides refers to all those isocyanides in which a neighbouring
functional group can finely tune the reactivity of the isocyano group or can be exploited in …

Chemistry and biology of multicomponent reactions

A Domling, W Wang, K Wang - Chemical reviews, 2012 - ACS Publications
Multicomponent reactions (MCRs) are one-pot reactions employing more than two starting
materials, for example, 3, 4,..., 7, where most of the atoms of the starting materials are …

DCAF11 supports targeted protein degradation by electrophilic proteolysis-targeting chimeras

X Zhang, LM Luukkonen, CL Eissler… - Journal of the …, 2021 - ACS Publications
Ligand-induced protein degradation has emerged as a compelling approach to promote the
targeted elimination of proteins from cells by directing these proteins to the ubiquitin …