Lipids and lipid derivatives for RNA delivery
Y Zhang, C Sun, C Wang, KE Jankovic… - Chemical reviews, 2021 - ACS Publications
RNA-based therapeutics have shown great promise in treating a broad spectrum of
diseases through various mechanisms including knockdown of pathological genes …
diseases through various mechanisms including knockdown of pathological genes …
Tetrazoles via multicomponent reactions
CG Neochoritis, T Zhao, A Domling - Chemical reviews, 2019 - ACS Publications
Tetrazole derivatives are a prime class of heterocycles, very important to medicinal
chemistry and drug design due to not only their bioisosterism to carboxylic acid and amide …
chemistry and drug design due to not only their bioisosterism to carboxylic acid and amide …
Delivery of mRNA vaccines with heterocyclic lipids increases anti-tumor efficacy by STING-mediated immune cell activation
Therapeutic messenger RNA vaccines enable delivery of whole antigens, which can be
advantageous over peptide vaccines. However, optimal efficacy requires both intracellular …
advantageous over peptide vaccines. However, optimal efficacy requires both intracellular …
Hydroxyapatite: A review of syntheses, structure and applications in heterogeneous catalysis
The synthesis of hydroxyapatite (HAP) and its applications in heterogeneous catalysis are
abridged in view of its demonstrated prowess and utility in chemical, material and industrial …
abridged in view of its demonstrated prowess and utility in chemical, material and industrial …
Consecutive multicomponent reactions for the synthesis of complex molecules
S Zhi, X Ma, W Zhang - Organic & Biomolecular Chemistry, 2019 - pubs.rsc.org
Multicomponent reactions (MCRs) involving a minimum of three reactants or reaction
centers are conducted in one pot and with a single operational step. This synthetic method …
centers are conducted in one pot and with a single operational step. This synthetic method …
Silver nanoparticles-decorated Preyssler functionalized cellulose biocomposite as a novel and efficient catalyst for the synthesis of 2-amino-4H-pyrans and …
S Saneinezhad, L Mohammadi, V Zadsirjan… - Scientific reports, 2020 - nature.com
Silver nanoparticles-decorated Preyssler functionalized cellulose biocomposite (PC/AgNPs)
was prepared and fully characterized by FTIR, UV–vis, SEM, and TEM techniques. The …
was prepared and fully characterized by FTIR, UV–vis, SEM, and TEM techniques. The …
Recent applications of the multicomponent synthesis for bioactive pyrazole derivatives
D Becerra, R Abonia, JC Castillo - Molecules, 2022 - mdpi.com
Pyrazole and its derivatives are considered a privileged N-heterocycle with immense
therapeutic potential. Over the last few decades, the pot, atom, and step economy (PASE) …
therapeutic potential. Over the last few decades, the pot, atom, and step economy (PASE) …
To each his own: isonitriles for all flavors. Functionalized isocyanides as valuable tools in organic synthesis
M Giustiniano, A Basso, V Mercalli… - Chemical Society …, 2017 - pubs.rsc.org
The term functionalized isocyanides refers to all those isocyanides in which a neighbouring
functional group can finely tune the reactivity of the isocyano group or can be exploited in …
functional group can finely tune the reactivity of the isocyano group or can be exploited in …
Chemistry and biology of multicomponent reactions
Multicomponent reactions (MCRs) are one-pot reactions employing more than two starting
materials, for example, 3, 4,..., 7, where most of the atoms of the starting materials are …
materials, for example, 3, 4,..., 7, where most of the atoms of the starting materials are …
DCAF11 supports targeted protein degradation by electrophilic proteolysis-targeting chimeras
X Zhang, LM Luukkonen, CL Eissler… - Journal of the …, 2021 - ACS Publications
Ligand-induced protein degradation has emerged as a compelling approach to promote the
targeted elimination of proteins from cells by directing these proteins to the ubiquitin …
targeted elimination of proteins from cells by directing these proteins to the ubiquitin …