ABSTRACT A large number of microbes exist in the gut and they have the ability to process
and utilize ingested food. It has been reported that their products are involved in colorectal …

Hydrogen sulfide (H2S) has a long history as toxic gas and environmental hazard; inhibition
of cytochrome c oxidase (mitochondrial Complex IV) is viewed as a primary mode of its …

An increase in intracellular Ca2+ concentration ([Ca2+] i) controls virtually all endothelial
cell functions and is, therefore, crucial to maintain cardiovascular homeostasis. An aberrant …

Colorectal carcinoma (CRC) represents the fourth most common cancer worldwide and is
the third most common cause of malignancy-associated mortality. Distant metastases to the …

Endothelial colony forming cells (ECFCs) represent the most suitable cellular substrate to
induce revascularization of ischemic tissues. Recently, optical excitation of the light-sensitive …

Transient receptor potential melastatin 4 (TRPM4) is widely expressed in various organs
and associated with cardiovascular and immune diseases. Lately, the interest in studies on …

Background The role of hydrogen sulfide (H2S) in cancer biology is controversial, including
colorectal cancer. The bell-shaped effect of H2S refers to pro-cancer action at lower doses …

Nitric oxide, carbon monoxide and hydrogen sulfide are three endogenous gasotransmitters
that serve a role in regulating normal and pathological cellular activities. They can stimulate …

Ion channels and transporters are ubiquitously expressed on cell membrane, which involve
in a plethora of physiological process such as contraction, neurotransmission, secretion and …

For a long time, hydrogen sulfide (H2S) has been considered a toxic compound, but recent
studies have found that H2S is the third gaseous signaling molecule which plays a vital role …