Small and large animal models in cardiac contraction research: advantages and disadvantages
N Milani-Nejad, PML Janssen - Pharmacology & therapeutics, 2014 - Elsevier
The mammalian heart is responsible for not only pumping blood throughout the body but
also adjusting this pumping activity quickly depending upon sudden changes in the …
also adjusting this pumping activity quickly depending upon sudden changes in the …
Structure, function and clinical relevance of the cardiac conduction system, including the atrioventricular ring and outflow tract tissues
H Dobrzynski, RH Anderson, A Atkinson… - Pharmacology & …, 2013 - Elsevier
It is now over 100years since the discovery of the cardiac conduction system, consisting of
three main parts, the sinus node, the atrioventricular node and the His–Purkinje system. The …
three main parts, the sinus node, the atrioventricular node and the His–Purkinje system. The …
Transcriptomic profiling of the developing cardiac conduction system at single-cell resolution
Rationale: The cardiac conduction system (CCS) consists of distinct components including
the sinoatrial node, atrioventricular node, His bundle, bundle branches, and Purkinje fibers …
the sinoatrial node, atrioventricular node, His bundle, bundle branches, and Purkinje fibers …
[HTML][HTML] Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencing
D Liang, J Xue, L Geng, L Zhou, B Lv, Q Zeng… - Nature …, 2021 - nature.com
Bioelectrical impulses intrinsically generated within the sinoatrial node (SAN) trigger the
contraction of the heart in mammals. Though discovered over a century ago, the molecular …
contraction of the heart in mammals. Though discovered over a century ago, the molecular …
Redundant and diverse intranodal pacemakers and conduction pathways protect the human sinoatrial node from failure
The human sinoatrial node (SAN) efficiently maintains heart rhythm even under adverse
conditions. However, the specific mechanisms involved in the human SAN's ability to …
conditions. However, the specific mechanisms involved in the human SAN's ability to …
Calsequestrin 2 deletion causes sinoatrial node dysfunction and atrial arrhythmias associated with altered sarcoplasmic reticulum calcium cycling and degenerative …
Aims Loss-of-function mutations in Calsequestrin 2 (CASQ2) are associated with
catecholaminergic polymorphic ventricular tachycardia (CPVT). CPVT patients also exhibit …
catecholaminergic polymorphic ventricular tachycardia (CPVT). CPVT patients also exhibit …
[HTML][HTML] Fibrosis: a structural modulator of sinoatrial node physiology and dysfunction
Heart rhythm is initialized and controlled by the Sinoatrial Node (SAN), the primary
pacemaker of the heart. The SAN is a heterogeneous multi-compartment structure …
pacemaker of the heart. The SAN is a heterogeneous multi-compartment structure …
What makes the sinoatrial node tick? A question not for the faint of heart
L Donald, EG Lakatta - Philosophical Transactions of the …, 2023 - royalsocietypublishing.org
Even before the sinoatrial node (SAN) was discovered, cardiovascular science was
engaged in an active investigation of when and why the heart would beat. After the …
engaged in an active investigation of when and why the heart would beat. After the …
Human sinoatrial node structure: 3D microanatomy of sinoatrial conduction pathways
Introduction Despite a century of extensive study on the human sinoatrial node (SAN), the
structure-to-function features of specialized SAN conduction pathways (SACP) are still …
structure-to-function features of specialized SAN conduction pathways (SACP) are still …
Pharmacologic approach to sinoatrial node dysfunction
P Mesirca, VV Fedorov, TJ Hund… - Annual review of …, 2021 - annualreviews.org
The spontaneous activity of the sinoatrial node initiates the heartbeat. Sino-atrial node
dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's …
dysfunction (SND) and sick sinoatrial (sick sinus) syndrome are caused by the heart's …