Undoubtedly, the advent of antibiotics in the 19th century had a substantial impact,
increasing human life expectancy. However, a multitude of scientific investigations now …

Natural products have historically been of crucial importance in the identification and
development of antibacterial agents. Interest in these systems has waned in recent years …

Antibiotics that use novel mechanisms are needed to combat antimicrobial resistance,–.
Teixobactin represents a new class of antibiotics with a unique chemical scaffold and lack of …

The microorganisms that have developed resistance to available therapeutic agents are
threatening the globe and multidrug resistance among the bacterial pathogens is becoming …

The natural antibiotic teixobactin kills pathogenic bacteria without detectable resistance. The
difficult synthesis and unfavourable solubility of teixobactin require modifications, yet …

To cope with the global bacterial multidrug resistance, scientific communities have devoted
significant efforts to develop novel antibiotics, particularly those with new modes of actions …

While the global market for peptide/protein-based therapeutics is witnessing significant
growth, the development of peptide drugs remains challenging due to their low oral …

Covering: 2015 to 2022 Staphylococcus aureus (S. aureus) is responsible for several
community and hospital-acquired infections with life-threatening complications such as …

Covering: up to 2017 History points to the bacterial cell wall biosynthetic network as a very
effective target for antibiotic intervention, and numerous natural product inhibitors have been …

This paper elucidates the teixobactin pharmacophore by comparing the arginine analogue
of teixobactin Arg10-teixobactin to seven homologues with varying structure and …