Cell polarity, the generation of cellular asymmetries, is necessary for diverse processes in
animal cells, such as cell migration, asymmetric cell division, epithelial barrier function, and …

Cell polarity is essential for cells to divide asymmetrically, form spatially restricted
subcellular structures and participate in three-dimensional multicellular organization. PAR …

Summary Bazooka (PAR-3), PAR-6, and aPKC form a complex that plays a key role in the
polarization of many cell types. In epithelial cells, however, Bazooka localizes below PAR-6 …

In a genome-wide RNA-mediated interference screen for genes required in membrane traffic—
including endocytic uptake, recycling from endosomes to the plasma membrane, and …

The capability to conditionally inactivate gene function is essential for understanding the
molecular basis of development. In gene and mRNA targeting approaches, protein products …

The establishment of an apical–basal axis of polarity is essential for the organization and
functioning of epithelial cells. Polarization of epithelial cells is orchestrated by a network of …

Background The centrosome is the major microtubule organizing center (MTOC) in dividing
cells and in many postmitotic, differentiated cells. In other cell types, however, MTOC …

Summary Background In Drosophila epithelial cells, specification and maintenance of the
zonula adherens (za) is crucial to ensure epithelial tissue integrity. This depends on the …

The apicobasal polarity of epithelial cells is critical for organ morphogenesis and function,
and loss of polarity can promote tumorigenesis. Most epithelial cells form when precursor …

The nematode worm Caenorhabditis elegans has produced a wellspring of insights into
mechanisms that govern cellular symmetry breaking during animal development. Here we …