Motivation One of the goals of functional genomics is to understand the regulatory
implications of experimentally obtained genomic regions of interest (ROIs). Most sequencing …

Alterations in histone modifications play a crucial role in the progression of various types of
cancer. The histone methyltransferase SETDB1 catalyzes the addition of methyl groups to …

Chromatin, the nucleoprotein complex consisting of DNA and histone proteins, plays a
crucial role in regulating gene expression by controlling access to DNA. Chromatin …

The genomic loci bound by the glucocorticoid receptor (GR), a hormone-activated
transcription factor, show little overlap between cell types. To study the role of chromatin and …

The application of mathematical modelling to chromatin-mediated gene regulation is gaining
momentum, but is still surprisingly rare. Here we review examples in which the combination …

Epigenetic communication through histone and cytosine modifications is essential for gene
regulation and cell identity. Here, we propose a framework that is based on a chromatin …

A cell's epigenome arises from interactions among regulatory factors—transcription factors
and histone modifications—co-localized at particular genomic regions. We developed a …

The present study was designed to investigate the relationship among epigenetic changes
in Wnt antagonists, histone H4K20me1 and the expression of tumor-suppressor genes in …

Post-translational modifications of proteins (PTMs) act as key regulators of protein activity
and of protein–protein interactions (PPIs). To date, it has been difficult to comprehensively …

Background. Legionella pneumophila is a causative agent of severe pneumonia. Infection
leads to a broad host cell response, as evident, for example, on the transcriptional level …