The use of high-throughput next-generation sequencing techniques in multiple tumor types
during the last few years has identified NTRK1, 2, and 3 gene rearrangements encoding …

Chromosomal rearrangements involving the NTRK1, NTRK2, and NTRK3 genes (NTRK
genes), which encode the high-affinity nerve growth factor receptor (TRKA), brain-derived …

The tropomyosin receptor kinase (TRK) family includes TRKA, TRKB, and TRKC proteins,
which are encoded by NTRK1, NTRK2 and NTRK3 genes, respectively. Binding of …

Lung cancer is a complex disease composed of diverse histological and molecular types
with clinical relevance. The advent of large-scale molecular profiling has been helpful to …

Activated ALK and ROS1 tyrosine kinases, resulting from chromosomal rearrangements,
occur in a subset of non–small cell lung cancers (NSCLC) as well as other tumor types and …

The neurotrophic tyrosine receptor kinase (NTRK) gene family encodes three tropomyosin
receptor kinases (TRKA, TRKB, TRKC) that contribute to central and peripheral nervous …

Anaplastic lymphoma kinase (ALK) is a receptor tyrosine kinase responsible for the
development of different tumor types. Despite the remarkable clinical activity of crizotinib …

Glioblastoma multiforme (GBM) is the deadliest form of brain tumor with a more than 90% 5‐
year mortality. GBM has a paltry median survival of 12.6 months attributed to the unique …

Fusions involving neurotrophic tyrosine receptor kinase (NTRK) genes are detected in≤ 2%
of gliomas and can promote gliomagenesis. The remarkable therapeutic efficacy of TRK …

The family of the neurotrophic tropomyosin kinase receptors (NTRK or TRK) is a part of the
transmembrane tyrosine kinases responsible for neuronal development. The members of …