Sequence-specific RNA-binding proteins (RBPs) bind to pre-mRNA to control alternative
splicing, but it is not yet possible to read the'splicing code'that dictates splicing regulation on …

One of the most amazing findings in molecular biology was the discovery that eukaryotic
genes are discontinuous, with coding DNA being interrupted by stretches of non-coding …

While the human transcriptome contains a large number of circular RNAs (circRNAs), the
functions of most circRNAs remain unclear. Sequence annotation suggests that most …

Pre-mRNA splicing is catalyzed by the spliceosome, a multimegadalton ribonucleoprotein
(RNP) complex comprised of five snRNPs and numerous proteins. Intricate RNA-RNA and …

The collection of components required to carry out the intricate processes involved in
generating and maintaining a living, breathing and, sometimes, thinking organism is …

Alternative splicing of mRNA precursors provides an important means of genetic control and
is a crucial step in the expression of most genes. Alternative splicing markedly affects human …

Ribonucleoproteins (RNPs) mediate key cellular functions such as gene expression and its
regulation. Whereas most RNP enzymes are stable in composition and harbor preformed …

The hnRNPs (heterogeneous nuclear ribonucleoproteins) are RNA-binding proteins with
important roles in multiple aspects of nucleic acid metabolism, including the packaging of …

One of the fundamental issues in RNA splicing research is represented by understanding
how the spliceosome can successfully define exons and introns in a huge variety of pre …

The molecular mechanisms of exon definition and back-splicing are fundamental
unanswered questions in pre-mRNA splicing. Here we report cryo-electron microscopy …