Cancer immunotherapy and vaccine development have significantly improved the fight
against cancers. Despite these advancements, challenges remain, particularly in the clinical …

The dysfunction of blood-vessel-lining endothelial cells is a major cause of mortality.
Although endothelial cells, being present in all organs as a single-cell layer, are often …

The majority of cancer patients receive radiotherapy during the course of treatment,
delivered with curative intent for local tumor control or as part of a multimodality regimen …

Stimulator of interferon genes (STING) is an immune adaptor protein that senses cyclic GMP-
AMP in response to self or microbial cytosolic DNA as a danger signal. STING is …

The cGAS-STING signaling pathway has emerged as a critical mediator of innate immune
responses, playing a crucial role in improving antitumor immunity through immune effector …

Although immunotherapy is relatively effective in treating hematological malignancies, their
efficacy against solid tumors is still suboptimal or even noneffective presently. Compared to …

Abstract The cGAS (cyclic GMP-AMP synthase)-STING (stimulator of interferon genes)
pathway promotes antitumor immune responses by sensing cytosolic DNA fragments leaked …

The low immunogenicity of tumors, along with the abnormal structural and biochemical
barriers of tumor-associated vasculature, impedes the infiltration and function of effector T …

Hypoxia is a pervasive feature of solid tumors, which significantly limits the therapeutic effect
of photodynamic therapy (PDT) and further influences the immunotherapy efficiency in …

The immunosuppressive microenvironment of malignant tumors severely hampers the
effectiveness of anti-tumor therapy. Moreover, abnormal tumor vasculature interacts with …