Mesoionic carbenes are a subclass of the family of N-heterocyclic carbenes that generally
feature less heteroatom stabilization of the carbenic carbon and hence impart specific donor …

History shows that metal-based drugs and remedies have been known and used since very
ancient times. For example, silver was employed in the treatment of wounds and ulcers …

The clinical success of platinum-based chemotherapeutic agents was of enormous impact
on the discovery of novel metal N-heterocyclic carbene (NHC) complexes as potential anti …

The clinical success of the platinum-based chemotherapeutic agents has prompted the
investigation of coordination and organometallic complexes of alternative metal centers for …

The popularity of RAPTA-C in in vivo studies has steered the way for complexes of the type
[Ru (η 6-arene)(X)(Y)(Z)] n+ (where X, Y and Z are monodentate ligands) to be developed …

Even though the existence of 1, 2, 3‐triazoles has been known for more than a century, the
recent discovery of a copper (I) catalyzed version of this reaction has attributed …

Late transition metal complexes that bear N-heterocyclic carbene (NHC) ligands have seen
a speedy growth in their use as both, metal-based drug candidates and potentially active …

Highlights•Osmium complexes are promising anticancer agents.•In vitro assays revealed
antiproliferative activity in nanomolar concentrations.•New leads of osmium are well …

Ruthenium compounds have unique physicochemical properties that can be efficiently
exploited in medicinal chemistry. These molecules can act using both DNA or enzymes as …

Metal complexes provide a versatile platform to develop novel anticancer pharmacophores,
and they form stable compounds with N-heterocyclic carbene (NHC) ligands, some of which …