Production of sperm and androgens is the main function of the testis. This depends on
normal development of both testicular somatic cells and germ cells. A genetic program …

Normal testicular function is dependent upon hormones acting through endocrine and
paracrine pathways both in vivo and in vitro. Sertoli cells provide factors necessary for the …

Congenital cryptorchidism (undescended testis) is one of the most common congenital
urogenital malformations in boys. Prevalence of cryptorchidism at birth among boys born …

To investigate further brain-pituitary-gonadal interrelationships we have generated mice in
which the gene encoding the FSH receptor has been disrupted. Female FSH receptor …

The recent availability of specific inhibin assays has demonstrated that inhibin B is the
relevant circulating inhibin form in the human male. Inhibin B is a dimer of an alpha and a …

When it was initially discovered in 1923, inhibin was characterized as a hypophysiotropic
hormone that acts on pituitary cells to regulate pituitary hormone secretion. Ninety years …

It has been 70 years since the name inhibin was used to describe a gonadal factor that
negatively regulated pituitary hormone secretion. The majority of this period was required to …

BACKGROUND The increase in the incidence of obesity has a substantial societal health
impact. Contrasting reports have been published on whether overweight and obesity affect …

The testes produce the male gametes and the male sexual hormones (androgens). The term
spermatogenesis describes and includes all the processes involved in the production of …

The somatic Sertoli cell plays an essential role in embryonic determination of male somatic
sex and in spermatogenesis during adult life. One individual Sertoli cell supplies a clone of …