Coordinated cellular neighborhoods orchestrate antitumoral immunity at the colorectal cancer invasive front
Antitumoral immunity requires organized, spatially nuanced interactions between
components of the immune tumor microenvironment (iTME). Understanding this coordinated …
components of the immune tumor microenvironment (iTME). Understanding this coordinated …
SABER amplifies FISH: enhanced multiplexed imaging of RNA and DNA in cells and tissues
Fluorescence in situ hybridization (FISH) reveals the abundance and positioning of nucleic
acid sequences in fixed samples. Despite recent advances in multiplexed amplification of …
acid sequences in fixed samples. Despite recent advances in multiplexed amplification of …
Exploring single cells in space and time during tissue development, homeostasis and regeneration
U Mayr, D Serra, P Liberali - Development, 2019 - journals.biologists.com
Complex 3D tissues arise during development following tightly organized events in space
and time. In particular, gene regulatory networks and local interactions between single cells …
and time. In particular, gene regulatory networks and local interactions between single cells …
The necessity and power of random, under-sampled experiments in biology
B Cleary, A Regev - arXiv preprint arXiv:2012.12961, 2020 - arxiv.org
A vast array of transformative technologies developed over the past decade has enabled
measurement and perturbation at ever increasing scale, yet our understanding of many …
measurement and perturbation at ever increasing scale, yet our understanding of many …
Automated multimodal fluorescence microscopy for hyperplex spatial-proteomics: Coupling microfluidic-based immunofluorescence to high resolution, high sensitivity …
L Furia, S Pelicci, F Perillo, MM Bolognesi… - Frontiers in …, 2022 - frontiersin.org
In situ multiplexing analysis and in situ transcriptomics are now providing revolutionary tools
to achieve the comprehension of the molecular basis of cancer and to progress towards …
to achieve the comprehension of the molecular basis of cancer and to progress towards …
Simultaneous amplification of multiple immunofluorescence signals via cyclic staining of target molecules using mutually cross-adsorbed antibodies
Amplification of immunofluorescence (IF) signals is becoming increasingly critical in cancer
research and neuroscience. Recently, we put forward a new signal amplification technique …
research and neuroscience. Recently, we put forward a new signal amplification technique …
SABER-FISH–Signal amplification for multiplexed fluorescence in situ hybridization assays
Abstract The SABER Technology The Signal Ampli cation By Exchange Reaction (SABER)
method is used for amplifying signal from multiplexed in situ uorescence staining …
method is used for amplifying signal from multiplexed in situ uorescence staining …