Gene therapy is the product of man's quest to eliminate diseases. Gene therapy has three
facets namely, gene silencing using siRNA, shRNA and miRNA, gene replacement where …

The oligonucleotide therapeutics field has seen remarkable progress over the last few years
with the approval of the first antisense drug and with promising developments in late stage …

Critical tissue defects frequently result from trauma, burns, chronic wounds and/or surgery.
The ideal treatment for such tissue loss is autografting, but donor sites are often limited …

RNA therapeutics (eg siRNA, oligonucleotides, mRNA, etc.) show great potential for the
treatment of a myriad of diseases. However, to reach their site of action in the cytosol or …

Gene delivery systems necessitate the gene therapy, which is a unique approach for
applying the tunable genes to treat any diseases. To tackle down the disadvantages of viral …

Exosomes are a subset of extracellular vesicles which accommodate a cargo of bioactive
biomolecules that generally includes proteins, nucleic acids, lipids, sugars, and related …

Introduction Loss of the cystic fibrosis transmembrane conductance regulator in cystic
fibrosis (CF) leads to hyperabsorption of sodium and fluid from the airway due to …

Protein-based targeted toxins play an increasingly important role in targeted tumor
therapies. In spite of their high intrinsic toxicity, their efficacy in animal models is low. A major …

The inhibition of ENaC may have therapeutic potential in CF airways by reducing sodium
hyperabsorption, restoring lung epithelial surface fluid levels, airway hydration and …

Food-derived peptides, as dietary supplements, have significant effects on promoting brain
health and relieving central nervous system (CNS) diseases. However, the blood–brain …