[HTML][HTML] Regulation of intestinal barrier function by microbial metabolites

S Ghosh, CS Whitley, B Haribabu, VR Jala - Cellular and molecular …, 2021 - Elsevier
The human gastrointestinal tract (GI) harbors a diverse population of microbial life that
continually shapes host pathophysiological responses. Despite readily available abundant …

Role of dietary polyphenols on gut microbiota, their metabolites and health benefits

SM Aravind, S Wichienchot, R Tsao… - Food Research …, 2021 - Elsevier
The beneficial health roles of dietary polyphenols in preventing oxidative stress related
chronic diseases have been subjected to intense investigation over the last two decades. As …

[HTML][HTML] Polyphenol-mediated gut microbiota modulation: toward prebiotics and further

MC Rodríguez-Daza, EC Pulido-Mateos… - Frontiers in …, 2021 - frontiersin.org
The genome of gut microbes encodes a collection of enzymes whose metabolic functions
contribute to the bioavailability and bioactivity of unabsorbed (poly) phenols. Datasets from …

[HTML][HTML] Impact of the natural compound urolithin A on health, disease, and aging

D D'Amico, PA Andreux, P Valdés, A Singh… - Trends in molecular …, 2021 - cell.com
Urolithin A (UA) is a natural compound produced by gut bacteria from ingested ellagitannins
(ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranate …

[HTML][HTML] The effects of vegetarian and vegan diets on gut microbiota

A Tomova, I Bukovsky, E Rembert, W Yonas… - Frontiers in …, 2019 - frontiersin.org
The difference in gut microbiota composition between individuals following vegan or
vegetarian diets and those following omnivorous diets is well documented. A plant-based …

[HTML][HTML] The interactions between polyphenols and microorganisms, especially gut microbiota

M Makarewicz, I Drożdż, T Tarko, A Duda-Chodak - Antioxidants, 2021 - mdpi.com
This review presents the comprehensive knowledge about the bidirectional relationship
between polyphenols and the gut microbiome. The first part is related to polyphenols' …

Bioactivity of dietary polyphenols: The role of metabolites

SV Luca, I Macovei, A Bujor, A Miron… - Critical reviews in …, 2020 - Taylor & Francis
A polyphenol-rich diet protects against chronic pathologies by modulating numerous
physiological processes, such as cellular redox potential, enzymatic activity, cell proliferation …

[HTML][HTML] Prebiotic effect of dietary polyphenols: A systematic review

AM Alves-Santos, CSA Sugizaki, GC Lima… - Journal of Functional …, 2020 - Elsevier
Prebiotics are substrates selectively metabolized by hindgut microorganisms conferring
health benefits. Recent studies suggest polyphenols as candidate to prebiotics. Thus, this …

[HTML][HTML] Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

R Singh, S Chandrashekharappa, SR Bodduluri… - Nature …, 2019 - nature.com
The importance of gut microbiota in human health and pathophysiology is undisputable.
Despite the abundance of metagenomics data, the functional dynamics of gut microbiota in …

The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

PA Andreux, W Blanco-Bose, D Ryu, F Burdet… - Nature …, 2019 - nature.com
Urolithin A (UA) is a natural dietary, microflora-derived metabolite shown to stimulate
mitophagy and improve muscle health in old animals and in preclinical models of aging …