Therapeutic trials for long COVID-19: A call to action from the interventions taskforce of the RECOVER initiative

H Bonilla, MJ Peluso, K Rodgers, JA Aberg… - Frontiers in …, 2023 - frontiersin.org
Although most individuals recover from acute SARS-CoV-2 infection, a significant number
continue to suffer from Post-Acute Sequelae of SARS-CoV-2 (PASC), including the …

The human gut microbiome in health and disease

J Jovel, LA Dieleman, D Kao, AL Mason, E Wine - Metagenomics, 2018 - Elsevier
The harmonic coexistence of microorganisms with the human body is the result of a long
coevolutionary process that has minimized competition for nutrients and immunological …

Targeting the latent reservoir for HIV-1

S Sengupta, RF Siliciano - Immunity, 2018 - cell.com
Antiretroviral therapy can effectively block HIV-1 replication and prevent or reverse
immunodeficiency in HIV-1-infected individuals. However, viral replication resumes within …

CXCL13 and its receptor CXCR5 in cancer: inflammation, immune response, and beyond

MG Kazanietz, M Durando, M Cooke - Frontiers in endocrinology, 2019 - frontiersin.org
It is well-established that the chemokine CXC motif ligand 13 (CXCL13) and its receptor, the
G-protein coupled receptor (GPCR) CXCR5, play fundamental roles in inflammatory …

Type I interferon in chronic virus infection and cancer

LM Snell, TL McGaha, DG Brooks - Trends in immunology, 2017 - cell.com
Type I interferons (IFN-Is) are emerging as key drivers of inflammation and
immunosuppression in chronic infection. Control of these infections requires IFN-I signaling; …

[HTML][HTML] CXCR5+ follicular cytotoxic T cells control viral infection in B cell follicles

YA Leong, Y Chen, HS Ong, D Wu, K Man… - Nature …, 2016 - nature.com
During unresolved infections, some viruses escape immunological control and establish a
persistant reservoir in certain cell types, such as human immunodeficiency virus (HIV), which …

Comparative analysis of activation induced marker (AIM) assays for sensitive identification of antigen-specific CD4 T cells

S Reiss, AE Baxter, KM Cirelli, JM Dan, A Morou… - PloS one, 2017 - journals.plos.org
The identification and study of antigen-specific CD4 T cells, both in peripheral blood and in
tissues, is key for a broad range of immunological research, including vaccine responses …

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

Y Fukazawa, R Lum, AA Okoye, H Park, K Matsuda… - Nature medicine, 2015 - nature.com
Chronic-phase HIV and simian immunodeficiency virus (SIV) replication is reduced by as
much as 10,000-fold in elite controllers (ECs) compared with typical progressors (TPs), but …

CD4+ T‐cell depletion in HIV infection: mechanisms of immunological failure

AA Okoye, LJ Picker - Immunological reviews, 2013 - Wiley Online Library
The hallmark of acquired immunodeficiency syndrome (AIDS) pathogenesis is a progressive
depletion of CD 4+ T‐cell populations in close association with progressive impairment of …

Sharing CD4+ T cell loss: when COVID-19 and HIV collide on immune system

X Peng, J Ouyang, S Isnard, J Lin… - Frontiers in …, 2020 - frontiersin.org
COVID-19 is a distinctive infection characterized by elevated inter-human transmission and
presenting from absence of symptoms to severe cytokine storm that can lead to dismal …