Cancer vaccines: between the idea and the reality

OJ Finn - Nature Reviews Immunology, 2003 - nature.com
Whether vaccines are designed to prepare the immune system for the encounter with a
pathogen or with cancer, certain common challenges need to be faced, such as what …

Emerging clinical applications of RNA

BA Sullenger, E Gilboa - Nature, 2002 - nature.com
RNA is a versatile biological macromolecule that is crucial in mobilizing and interpreting our
genetic information. It is not surprising then that researchers have sought to exploit the …

mRNA is an endogenous ligand for Toll-like receptor 3

K Karikó, H Ni, J Capodici, M Lamphier… - Journal of Biological …, 2004 - ASBMB
Toll-like receptors (TLRs) are the basic signaling receptors of the innate immune system.
They are activated by molecules associated with pathogens or injured host cells and tissue …

Engineered nucleic acids encoding a modified erythropoietin and their expression

JP Schrum, NB Afeyan, GJ Sieczkiewicz… - US Patent …, 2014 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
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Immunological and clinical responses in metastatic renal cancer patients vaccinated with tumor RNA-transfected dendritic cells

Z Su, J Dannull, A Heiser, D Yancey, S Pruitt, J Madden… - Cancer research, 2003 - AACR
Autologous dendritic cells transfected with total renal tumor RNA have been shown to be
potent stimulators of CTLs and antitumor immunity in vitro. A Phase I trial was conducted to …

Terminally modified RNA

T Chakraborty, S Bancel, SG Hoge, A Roy… - US Patent …, 2017 - Google Patents
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Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells

J Dannull, Z Su, D Rizzieri, BK Yang… - The Journal of …, 2005 - Am Soc Clin Investig
In this study, we investigated whether elimination of CD4+/CD25+ Tregs using the
recombinant IL-2 diphtheria toxin conjugate DAB389IL-2 (also known as denileukin diftitox …

Engineered nucleic acids and methods of use thereof

JP Schrum, S Bancel, NB Afeyan - US Patent 8,822,663, 2014 - Google Patents
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C (= O) C (NC (= O)
C (CCC (N)= O) NC (= O) C (CCC (O)= O) NC (= O) C (C (C) C) NC (= O) C (NC (= O) CN) C …

Autologous dendritic cells transfected with prostate-specific antigen RNA stimulate CTL responses against metastatic prostate tumors

A Heiser, D Coleman, J Dannull… - The Journal of …, 2002 - Am Soc Clin Investig
Autologous dendritic cells (DCs) transfected with mRNA encoding prostate-specific antigen
(PSA) are able to stimulate potent, T cell–mediated antitumor immune responses in vitro. A …

Modified polynucleotides for the production of biologics and proteins associated with human disease

S Bancel, T Chakraborty, A De Fougerolles… - US Patent …, 2015 - Google Patents
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