Exploring the efficacy of natural products in alleviating Alzheimer's disease

P Deshpande, N Gogia, A Singh - Neural regeneration research, 2019 - journals.lww.com
Alzheimer's disease (hereafter AD) is a progressive neurodegenerative disorder that affects
the central nervous system. There are multiple factors that cause AD, viz., accumulation of …

My what big eyes you have: How the Drosophila retina grows

JP Kumar - Developmental neurobiology, 2011 - Wiley Online Library
The compound eye of the fruit fly, Drosophila melanogaster, has for decades been used
extensively to study a number of critical developmental processes including tissue …

N-Acetyltransferase 9 ameliorates Aβ42-mediated neurodegeneration in the Drosophila eye

P Deshpande, AV Chimata, E Snider, A Singh… - Cell Death & …, 2023 - nature.com
Abstract Alzheimer's disease (AD), a progressive neurodegenerative disorder, manifests as
accumulation of amyloid-beta-42 (Aβ42) plaques and intracellular accumulation of …

[HTML][HTML] Inactivation of Hippo and cJun-N-terminal Kinase (JNK) signaling mitigate FUS mediated neurodegeneration in vivo

N Gogia, A Sarkar, AS Mehta, N Ramesh… - Neurobiology of …, 2020 - Elsevier
Abstract Amyotrophic Lateral Sclerosis (ALS), a late-onset neurodegenerative disorder
characterized by the loss of motor neurons in the central nervous system, has no known cure …

Drosophila Eye Model to Study Neuroprotective Role of CREB Binding Protein (CBP) in Alzheimer's Disease

T Cutler, A Sarkar, M Moran, A Steffensmeier, OR Puli… - PloS one, 2015 - journals.plos.org
Background The progressive neurodegenerative disorder Alzheimer's disease (AD)
manifests as loss of cognitive functions, and finally leads to death of the affected individual …

Hippo signaling: bridging the gap between cancer and neurodegenerative disorders

N Gogia, AV Chimata, P Deshpande… - Neural Regeneration …, 2021 - journals.lww.com
During development, regulation of organ size requires a balance between cell proliferation,
growth and cell death. Dysregulation of these fundamental processes can cause a variety of …

miR-277 targets the proapoptotic gene-hid to ameliorate Aβ42-mediated neurodegeneration in Alzheimer's model

P Deshpande, CY Chen, AV Chimata, JC Li… - Cell Death & …, 2024 - nature.com
Abstract Alzheimer's disease (AD), an age-related progressive neurodegenerative disorder,
exhibits reduced cognitive function with no cure to date. One of the reasons for AD is the …

Lobe and Serrate are required for cell survival during early eye development in Drosophila

A Singh, X Shi, KW Choi - 2006 - journals.biologists.com
Organogenesis involves an initial surge of cell proliferation, leading to differentiation. This is
followed by cell death in order to remove extra cells. During early development, there is little …

A glimpse into dorso‐ventral patterning of the Drosophila eye

A Singh, M Tare, OR Puli… - Developmental …, 2012 - Wiley Online Library
During organogenesis in all multi‐cellular organisms, axial patterning is required to
transform a single layer organ primordium into a three‐dimensional organ. The Drosophila …

Unraveling Alzheimer's Disease Using Drosophila

CJ Yeates, A Sarkar, M Kango-Singh… - Insights into Human …, 2019 - Springer
Alzheimer's disease (AD) is a debilitating neurodegenerative disorder that predominantly
affects people aged over 65 years. AD is marked by cognitive deficits and memory problems …