The effects of Ro 40-5967, a nondihydropyridine Ca++ channel blocker, on low-voltage
activated (T-type) and high-voltage activated (L-type) Ca++ channels were compared. L-type …

Sequences specific for cyclic nucleotide-gated channels (CNG channels) have been
amplified by PCR from cDNA of heart, aorta, sinoatrial node, cerebellum, C-cells and kidney …

I. Introduction E XTRACELLULAR Ca2+ ([Ca2+] e) as well as intracellular calcium ([Ca2+] i)
play an essential role in stimulussecretion coupling in endocrine cells, stimulus-contraction …

Human calcitonin release is promoted by elevated extracellular Ca2+ (Ca2+ o)
concentration acting, at least in part, via the calcium-sensing receptor (CaSR). The CaSR is …

Ca2+ influx via voltage-dependent Ca2+ channels is known to be elicited during action
potentials but possibly also occurs at the resting potential. The steady-state current through …

Medullary thyroid carcinoma (MTC) is a tumor of the calcitonin (CT)-secreting cells (C-cells
or parafollicular cells). During embryogenesis C-cells migrate from the neural crest to the …

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Somatostatin has recently been applied therapeutically for hypercalcitonemia in patients
with calcitonin-producting tumours. Using calcitonin-secreting cells (C-cells) of the medullary …

The effect of somatostatin on cAMP accumulation and calcitonin secretion in C-cells of the
rat medullary thyroid carcinoma cell line rMTC 6–23 was investigated. Intracellular cAMP …

The spontaneous electrical activity of calcitonin-secreting cells (C-cells) appears to play an
important role in the coupling of fluctuations in the extracellular Ca 2+ to changes in the …