Alzheimer's disease (AD) is the most common form of dementia among the elderly,
accounting for 60% to 70% of cases. At present, the pathogenesis of this condition remains …

The rapidly growing interest in kinases as drug targets has prompted the development of
many kinase assay technologies. These technologies can be grouped into three categories …

ADP-Glo™ is a novel bioluminescent, homogeneous assay for monitoring ADP producing
biochemical reactions and thus it is an ideal assay for detecting enzyme activity using a wide …

Based on a multitarget strategy, a series of novel tacrine–pyrimidone hybrids were identified
for the potential treatment of Alzheimer's disease (AD). Biological evaluation results …

Several findings propose the altered tau protein network as an important target for
Alzheimer's disease (AD). Particularly, two points of pharmacological intervention can be …

Cumulative evidence strongly supports that the amyloid and tau hypotheses are not mutually
exclusive, but concomitantly contribute to neurodegeneration in Alzheimer′ s disease (AD) …

Twenty-one known Amaryllidaceae alkaloids of various structural types and one
undescribed alkaloid, named narcimatuline, have been isolated from fresh bulbs of …

The multitarget approach has gained increasing acceptance as a useful tool to address
complex and multifactorial maladies such as Alzheimer's disease (AD). The concurrent …

The MTT/MTS in vitro cell proliferation assay is one of the most widely used assays for
evaluating preliminary anticancer activity of both synthetic derivatives and natural products …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease where motor neurons in
cortex, brain stem, and spinal cord die progressively, resulting in muscle wasting, paralysis …